REVIEW article
Front. Oncol.
Sec. Gastrointestinal Cancers: Gastric and Esophageal Cancers
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1678681
Advances in Glycolysis Research in Gastric Cancer: Molecular Mechanisms, Regulatory Networks, and Therapeutic Potential
Provisionally accepted
Jungang Dong*
Liang MaWeiyan LIJinrong YangDecheng Gan*Haixia XueLi PuLili ZhangKelan ZhangYonglong Jia- Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou, China
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Glycolysis is a central metabolic pathway in cancer cells, contributing significantly to the initiation, progression, and therapeutic resistance of gastric cancer. Advances in molecular biology and metabolomics have clarified the regulatory landscape of glycolysis, particularly its interactions with the tumor microenvironment and key signaling pathways. However, important gaps remain in understanding the precise functions and interactions of key regulatory factors. This review presents an overview of recent progress in glycolysis research in gastric cancer, focusing on essential regulators such as CENPU, CD73, SALL4, and MAOA, non-coding RNAs (e.g., circRNAs, lncRNAs, and miRNAs), and exosome-mediated metabolic reprogramming driven by tumor-associated macrophages. It also discusses the prognostic value of glycolysis-related genes and their potential as therapeutic targets, including the application of natural compounds and small-molecule inhibitors in anti-glycolytic strategies. These findings provide valuable insights into the metabolic mechanisms underlying gastric cancer and highlight the potential for developing metabolism-targeted therapies.
Keywords: gastric cancer, Glycolysis, Warburg effect, non-coding RNA, tumormetabolism, therapeutic targets
Received: 03 Aug 2025; Accepted: 29 Sep 2025.
Copyright: © 2025 Dong, Ma, LI, Yang, Gan, Xue, Pu, Zhang, Zhang and Jia. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Jungang Dong, 1551358797@qq.com
Decheng Gan, 363255771@qq.com
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.