ORIGINAL RESEARCH article
Front. Oncol.
Sec. Pediatric Oncology
Higher diversity and abundance of microRNA-455-5p isoforms confer suppressive role in Wilms' tumour
Provisionally accepted
- Children's Hospital of Soochow University, Suzhou, China
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MicroRNA isoforms (isomiRs) exhibit differential expression across tissues, populations, genders, and health and disease states, particularly influencing tumourigenesis and therapy. In this study, we have systematically analyzed the isomiRs present in specimens of pediatric Wilms' tumours (WT) based on Therapeutically Applicable Research to Generate Effective Treatments (TARGET) data, and further investigated their downstream target genes in silico studies. The results showed that a greater diversity and abundance of miR-455-5p isoforms were more closely associated with WT compared to its archetype. Patients exhibiting a higher variety and number of iso-miR-455-5p demonstrated superior survival rates, irrespective of tumour differentiation. Intriguingly, compared to the archetype of miR-455-5p, miR-455-5p 0|1 demonstrated enhanced complementarity to its target gene SP100, affects the histological classification of WT by regulating SP100. Consequently, it can be concluded that the diversity and abundance of miR-455-5p isoforms may play a more significant inhibitory role.
Keywords: Wilms' tumors, microRNA, isoform, MiR-455-5p, Sp100
Received: 07 Aug 2025; Accepted: 26 Nov 2025.
Copyright: © 2025 Chen, Zhou, Yao, Li, Wang, Zhou and Ni. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Hengli Ni
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