CASE REPORT article
Front. Oncol.
Sec. Gastrointestinal Cancers: Hepato Pancreatic Biliary Cancers
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1682054
Splenic Angiosarcoma With Hepatic and Cardiac Metastases: A Case Report and Literature Review
Provisionally accepted
- 1Second Hospital of Hebei Medical University, Shijiazhuang, China
- 2The Third Hospital of Hebei Medical University, Shijiazhuang, China
- 3The Second Hospital of Hebei Medical University, Shijiazhuang, China
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Splenic angiosarcoma (SA) is an rare malignant tumor in clinical practice, characterized by high malignancy, atypical early symptoms, and a dismal prognosis. In recent years, growing attention has been focused on its diagnosis and treatment. This report describes a patient who was admitted to the hospital due to left upper abdominal pain. Contrast-enhanced CT indicated unevenly enhanced tumors in the spleen, liver, and right atrium. The patient was treated with laparoscopic splenectomy + partial hepatectomy and was diagnosed based on postoperative pathology and immunohistochemistry (positive for CD31 and CD34). After the operation, anlotinib + toripalimab targeted immunotherapy was used, and the patient recovered well. This case suggests that SA is prone to metastasis in the early stage. Clinically, the diagnosis of SA requires a combination of pathological diagnosis and imaging diagnosis, and postoperative targeted immunotherapy may improve the prognosis.
Keywords: Angiosarcoma, cardiac tumor, liver metastasis tumor, Splenic tumor, Splenic imaging
Received: 08 Aug 2025; Accepted: 13 Oct 2025.
Copyright: © 2025 Chen, Chen, Yu, Wang, Wang and Haitao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Lv Haitao, gandanlvhaitao@163.com
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