ORIGINAL RESEARCH article
Front. Oncol.
Sec. Thoracic Oncology
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1685591
Effects of Evidence-Based Nursing Under a Quantitative Assessment Strategy on Cancer-Related Fatigue, Self-Management Ability, and Quality of Life in Lung Cancer Patients Undergoing Chemotherapy
Provisionally accepted
- The First Hospital of Hebei Medical University, Shijiazhuang, China
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Objective: To investigate the effects of evidence-based nursing under a quantitative assessment strategy (EB-NQAS) on cancer-related fatigue (CRF), self-management ability, quality of life (QoL), and adverse events in lung cancer patients undergoing chemotherapy. Methods: A single-center, prospective, randomized controlled trial (RCT) was conducted, enrolling 150 lung cancer patients undergoing chemotherapy between January 2024 and January 2025. Participants were randomized into the intervention group (n=75) and control group (n=75) using a random number table. The intervention group received EB-NQAS, which featured personalized care plans based on symptom quantification via the Edmonton Symptom Assessment Scale (ESAS), while the control group received routine nursing care. Outcomes were assessed at baseline and 3 months. CRF was assessed using the Piper Fatigue Scale (PFS), self-management ability via the Adult Health Self-Management Scale (AHSMSRS), and QoL via the European Organization for Research and Treatment of Cancer Quality of Life Core Questionnaire (EORTC-QLQ-C30). Adverse events were recorded. Data were analyzed using linear mixed-effects models and chi-square tests. Results: Analyses were conducted on all 150 randomized participants per the intention-to-treat principle. After 3 months, the EB-NQAS group showed a significantly greater reduction in the total PFS score compared to the control group (22.88±1.72 vs. 25.36±1.63; group × time interaction, P<0.001). The intervention group also demonstrated significantly greater improvements in total AHSMSRS scores (146.00±9.77 vs. 128.45±12.45) and global health status/QoL scores (77.66±9.74 vs. 68.91±9.51) than the control group (all group × time interactions, P<0.001). The incidence of gastrointestinal reactions in the intervention group (5.33%) was lower than that in the control group (18.67%, P=0.012). No significant differences were observed in other adverse events (P>0.05). Conclusion: Evidence-based nursing under a quantitative assessment strategy effectively reduces CRF, improves self-management ability and QoL, and decreases gastrointestinal reactions in lung cancer patients undergoing chemotherapy, demonstrating strong potential for clinical application.
Keywords: Evidence-Based Nursing, Quantitative Assessment Strategy, lung cancer, chemotherapy, Cancer-related fatigue
Received: 14 Aug 2025; Accepted: 10 Oct 2025.
Copyright: © 2025 Zhang, Fang, Zhang, Su, Zhang, He, Bo, Yan, Liu and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Feifei Wang, wangffhb@outlook.com
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