CASE REPORT article
Front. Oncol.
Sec. Gastrointestinal Cancers: Colorectal Cancer
This article is part of the Research TopicInnovations in Managing Retroperitoneal Tumors: Strategies from Surgery to Systemic TherapyView all articles
Primary Epithelioid Angiosarcoma of the Jejunum Presenting with Severe Anemia and Distant Metastasis: A Case Report and Literature Review
Provisionally accepted
- 1First Hospital, Peking University, Beijing, China
- 2Peking University First Hospital, Beijing, China
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Angiosarcoma (AS), constituting approximately 2% of all soft-tissue sarcomas, is an aggressive endothelial malignancy. We report the case of a 72-year-old male admitted with persistent melena and severe anemia, ultimately diagnosed with jejunal angiosarcoma (JAS) and associated lung and bone metastases. Temporary stabilization of his hemoglobin level was achieved via fasting, hemostasis, and blood transfusion. Initial plain CT identified multifocal solid lung nodules, yet failed to reveal a primary digestive system lesion. Subsequent small enteroscopy localized a submucosal bulge in the jejunum, 70 cm from the pylorus. Following partial small bowel resection, pathological examination confirmed a 0.9 × 0.8 × 0.7 cm angiosarcoma invading the intestinal wall and lamina propria. Immunohistochemical (IHC) staining showed strong positivity for CD31 (++), alongside CD34 (vascular+) and ERG (+). This report reviews the recent literature on JAS, summarizing diagnostic and therapeutic strategies.
Keywords: Anemia, Angiosarcoma, Biopsy, Enteroscopy, Jejunum
Received: 30 Sep 2025; Accepted: 11 Dec 2025.
Copyright: © 2025 Shurong, junling and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Xin Wang
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