REVIEW article
Front. Oncol.
Sec. Skin Cancer
This article is part of the Research TopicImmune-Related Biomarkers in Skin and Breast Cancer: Innovations in Immunological Diagnostics and TherapiesView all 9 articles
Application of transcriptomics techniques in skin cancer
Provisionally accepted
- 1Ningbo University, Ningbo, China
- 2The First Affiliated Hospital of Ningbo University, Ningbo, China
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Skin cancer is one of the most common malignant tumors worldwide, with its mortality rate showing a significant upward trend, thereby increasing the disease burden on patients and society. With the rapid development of next-generation sequencing technology, transcriptomics has revealed complex disease mechanisms by analyzing the expression patterns of differentially expressed genes, providing important tools for exploring the occurrence and development of skin cancer, studying the tumor microenvironment, investigating drug resistance mechanisms, and optimizing treatment strategies for skin cancer. This article aims to briefly summarize the development history of transcriptomics technology, review its research progress in skin cancer, and contribute to a more comprehensive understanding of the mechanisms underlying skin cancer development. It also holds promise for identifying potential therapeutic targets and providing new insights for clinical treatment of skin cancer.
Keywords: Skin Cancer, Transcriptomics, Single-cell transcriptomics, Spatial transcriptomics, Melanoma, basal cell carcinoma, squamous cell carcinoma of the skin
Received: 19 Aug 2025; Accepted: 14 Nov 2025.
Copyright: © 2025 Ma, Wang and Xu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Suling Xu, xusuling@nbu.edu
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