CASE REPORT article
Front. Oncol.
Sec. Breast Cancer
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1692891
Case Report: A Rare Case of Thyroid Metastasis from Breast Cancer
Provisionally accepted
- First Affiliated Hospital of Jilin University, Changchun, China
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Introduction: To analyze the clinicopathological features, diagnosis, and treatment strategies for metastatic breast carcinoma to the thyroid (MBCT) to enhance clinical awareness of this rare condition. Methods: Analysis of clinical data from one MBCT patient and literature review. Results: A 41-year-old female with left breast invasive ductal carcinoma (IDC) received neoadjuvant AC-T chemotherapy, breast-conserving surgery, radiotherapy, and endocrine therapy. At eight years post-diagnosis, thyroid lesions were detected. Total thyroidectomy with lymph node dissection confirmed MBCT pathologically. No progression was observed at 16 months post-thyroidectomy. Conclusions: MBCT is a rare clinical entity characterized by nonspecific clinical and radiological findings. Immunohistochemical (IHC) analysis is essential for a definitive diagnosis. In patients with a breast cancer history, MBCT should always be considered in the differential diagnosis of thyroid abnormalities.
Keywords: breast cancer, Metastatic Breast Carcinoma to the Thyroid, Diagnostic challenge, case, literature review
Received: 27 Aug 2025; Accepted: 13 Oct 2025.
Copyright: © 2025 Gao, Li, Hong, Wu, Fu and Song. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Dong Song, songdong@jlu.edu.cn
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