CASE REPORT article
Front. Oncol.
Sec. Gastrointestinal Cancers: Hepato Pancreatic Biliary Cancers
Functional Pancreatic Neuroendocrine Tumors Predominantly Presenting with Hypercalcemia: A Case Report
Provisionally accepted
- The Second Affiliated Hospital of Kunming Medical University, Kunming, China
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Functional pancreatic neuroendocrine tumors (F-PNETs) that secrete parathyroid hormone-related protein (PTHrP) and cause hypercalcemia are extremely rare. This report details a 10-year course of a patient with pancreatic neuroendocrine tumor (PNET) and recurrent life-threatening hypercalcemia. Moreover, it comprehensively describes the evolution and management of hypercalcemia in this case, aiming to offer valuable insights for clinical diagnosis and treatment.
Keywords: Functional Pancreatic Neuroendocrine Tumors, Hypercalcemia, Parathyroid Hormone-Related Protein, Parathyroid Hormone, continuous renal replacement therapy
Received: 26 Aug 2025; Accepted: 17 Nov 2025.
Copyright: © 2025 Duan, Zhu, Tang, Kui and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Ying-mei Tang, tangyingmei_med@kmmu.edu.cn
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