CASE REPORT article
Front. Oncol.
Sec. Gastrointestinal Cancers: Colorectal Cancer
This article is part of the Research TopicUnleashing Immunity against Cancer: New Horizons in ImmunotherapyView all 8 articles
Neoadjuvant Therapy with Cadonilimab in a Patient with MSI-H/dMMR Colorectal Cancer: A Case Report
Provisionally accepted
- Department of Colorectal Surgery, the Third Affiliated Hospital, School of PublicHealth, Kunming Medical University, Kunming, China
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Abstract: Neoadjuvant immunotherapy for mismatch repair-deficient/microsatellite instability-high (dMMR/MSI-H) colorectal cancer continues to accumulate compelling clinical evidence. This report presents the case of a 37-year-old female who presented with moderate anemia (hemoglobin: 69 g/L) and was subsequently diagnosed with dMMR/MSI-H descending colon cancer. Following nine cycles of cadonilimab, a novel PD-1/CTLA-4 bispecific antibody, the patient achieved significant tumor regression and subsequent pathological complete response (pCR) after surgery, with a favorable safety profile observed throughout the treatment course. This case provides valuable clinical evidence supporting the efficacy and safety of cadonilimab in the neoadjuvant setting for dMMR/MSI-H colorectal cancer.
Keywords: colorectal cancer, Cadonilimab, immune checkpoint inhibitors, eoadjuvant Immunotherapy, Pathological complete response, Programmed death-1(PD-1), Cytotoxic T-Lymphocyte-Associated Antigen 4(CTLA-4)
Received: 02 Sep 2025; Accepted: 21 Nov 2025.
Copyright: © 2025 Zhou, Shen, Chen, Wang, Ziwei, Guo and Zhuang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Tao Shen, shentao@kmmu.edu.cn
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