CASE REPORT article
Front. Oncol.
Sec. Gastrointestinal Cancers: Gastric and Esophageal Cancers
A Case Report of Ménétrier's Disease in an Adult and a Comprehensive Literature Review
Provisionally accepted
- 1Lanzhou University, Lanzhou, China
- 2Gansu Provincial Hospital, Lanzhou, China
- 3Gansu University of Chinese Medicine, Lanzhou, China
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Objective and Methods: This study conducted a retrospective analysis of the clinical data of a patient with MD at our hospital and reviewed relevant literature on MD. It explored the clinical characteristics, endoscopic and pathological manifestations of adult Ménétrier's disease (MD) to deepen understanding of this disease. Results: The patient exhibited typical clinical manifestations and endoscopic features of MD, and the diagnosis was confirmed by pathological characteristics. A review of the literature indicates that MD is characterized by hyperplasia of the gastric mucosa. Endoscopic examination reveal congestion and distortion, while histological analysis typically shows marked hyperplasia of gastric mucosal gland cells and crypts, with cystic dilatation at the base. The specific pathogenesis and treatment regimen for MD remain unclear at present. Conclusion: MD is a rare acquired condition characterized by thickening of the gastric mucosal folds. Histopathologically characterized by gastric pit hyperplasia, with a decrease in chief cells Corresponding author: Ping Mai, Department of gastroenterology, Gansu Provincial Hospital, No. 204, Donggang West Road, Chengguan District, Lanzhou City, Gansu Province, China. E-mail: maiping_lz@163.com. and parietal cells. The clinical presentation predominantly features gastrointestinal symptoms, often accompanied by hypoproteinemia. Diagnosis relies on deep gastroscopic biopsy and Histopathological examination. Empirical medical supportive therapy as the primary treatment approach in numerous cases. In cases that are challenging to manage or where there is an increased risk of cancer, partial or total gastrectomy may be considered as an option.
Keywords: Ménétrier's disease, Hypertrophy, Adult, Hypoalbuminemia, Epidermialgrowth factor receptor
Received: 30 Aug 2025; Accepted: 12 Nov 2025.
Copyright: © 2025 Ma, Liu, Cui and Ping. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Mai Ping, maiping_lz@163.com
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