CASE REPORT article
Front. Oncol.
Sec. Radiation Oncology
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1697902
This article is part of the Research TopicRadiation Spatial Fractionation—A novel approach to integrate Physics, Biology, and Immunology for high therapeutic index radiotherapyView all 6 articles
Case Report: Complete Pathologic Response in Advanced Melanoma with SFRT and Dual Checkpoint Inhibition
Provisionally accepted
Jared Hobson*
Michael P. Grams
Joanina GicobiDennis WigleLisa A KottschadeLindsey A DurhamKimberly Corbin
Haidong Dong
Svetomir N Markovic*
Sean Park*- Mayo Clinic, Rochester, United States
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Immune checkpoint inhibitors (ICIs) have transformed the treatment landscape for advanced melanoma, though response rates remain limited in bulky disease. Herein, we report the case of a complete pathologic response following combination spatially fractionated radiation therapy (SFRT) and dual nivolumab and ipilimumab for a 12cm right lung melanoma mass, with subsequent lobectomy revealing no viable tumor cells. Now disease free 2.5 years after treatment, including more than 1 year off all systemic therapy, this case highlights the potential synergy between SFRT and immunotherapy in advanced melanoma management.
Keywords: case report, Melanoma, SFRT, Radiation, Immunotherapy
Received: 02 Sep 2025; Accepted: 03 Oct 2025.
Copyright: © 2025 Hobson, Grams, Gicobi, Wigle, Kottschade, Durham, Corbin, Dong, Markovic and Park. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Jared Hobson, hobson.jared@mayo.edu
Svetomir N Markovic, markovic.svetomir@mayo.edu
Sean Park, park.sean@mayo.edu
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.