ORIGINAL RESEARCH article
Front. Oncol.
Sec. Cancer Imaging and Image-directed Interventions
Risk factor analysis of childhood and adolescent thyroid cancer mediastinal lymph node and distant metastasis
Provisionally accepted
- Henan Cancer Hospital Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, China
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Objective: The aim of this study is to explore the risk factors related to mediastinal lymph node metastasis (MLNM) and distant metastasis (DM) in children and adolescents with thyroid cancer. Method: This is a retrospective analysis of children and adolescent thyroid cancer patients admitted to our hospital from January 2015 to October 2022. The clinical and pathological data, and the preoperative ultrasound features of the patients were statistically analyzed. Results: This study included a total of 67 patients, consisting of 20 males and 47 females. Among them, 14 cases (20.9%) had mediastinal lymph node metastasis and 21 cases (31.3%) had distant metastasis. The univariate analysis showed that gender, the central metastatic lymph node ratio (CCLNR), and DM were all correlated in MLNM. The nodule morphology, location, the CCLNR, and MLNM were identified as related factors in DM. The multivariate regression results showed that gender and DM were independent MLNM risk factors. Furthermore, the lesion morphology and the CCLNR were identified as independent DM risk factors. Conclusion: The larger the CCLNR ratio, the higher the likelihood of the development MLNM and DM in children and adolescent thyroid cancer patients. A CCLNR > 0.79 as an evaluation index can indicate that children and adolescents with thyroid cancer are at higher risk of developing MLNM and DM.
Keywords: thyroid cancer, Children, Ultrasonography, metastasis, Lymph Node
Received: 14 Sep 2025; Accepted: 06 Nov 2025.
Copyright: © 2025 Zhang, Sun, Ding, Niu, Wang and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Qian Li, 754427296@qq.com
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