CASE REPORT article
Front. Oncol.
Sec. Cancer Molecular Targets and Therapeutics
This article is part of the Research TopicUnveiling the Complexity of Neuroendocrine Neoplasms: Biomarkers, Classification, and Translational PerspectivesView all 5 articles
TP53 Heterogeneous Alteration in Grade 3 Type Ⅰ Gastric NET: A Case Implicating Primary Tumor Progression
Provisionally accepted
- 1Beijing Haidian Hospital, Peking University, Haidian, China
- 2Haidian District of Peking University Third Hospital, Beijing, China, Beijing, China
- 3Peking University First Hospital, Beijing, China
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Grade 3(G3) type Ⅰ gastric neuroendocrine tumors (NETs) are rare, with only three documented cases in the literature to our knowledge. The case we report involves a type Ⅰ gastric NET(g-NET) classified as G3, which exhibits heterogeneity in TP53 gene mutations. This suggests that G3 g-NETs may develop from G2 forms. In this tumor located in the gastric body, both G2 and G3 components coexist. The G2 component is found in the superficial mucosa and submucosa, while the G3 component is in the submucosa and muscularis propria. Genetic testing reveals that the TP53 gene is mutated in the G3 component. The coexistence of these alterations within a single primary tumor is extremely rare, indicating that the TP53 gene plays a crucial role in the progression from G2 NET to G3 NET. This case may challenge our previous understanding of g-NETs.
Keywords: Neuroendocrine tumor grade 3, TP53 mutation, autoimmune metaplastic atrophic gastritis, Gastric neuroendocrine tumor (GNET), pathological factors
Received: 19 Sep 2025; Accepted: 18 Nov 2025.
Copyright: © 2025 Li, Bai, Ti, Zhou, Liu and Dong. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yan Li, li_blue@sina.com
Ying Dong, professor_dong@sina.com
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