SYSTEMATIC REVIEW article
Front. Oncol.
Sec. Gastrointestinal Cancers: Gastric and Esophageal Cancers
Comparison of the efficacy of different treatments after non-curative endoscopic resection of superficial esophageal carcinoma: a meta-analysis
Provisionally accepted
- 1Shandong Second Medical University, Weifang, China
- 2Qingdao Hospital of Peking University People's Hospital, QingDao, China
- 3Linyi People's Hospital, Linyi, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Objective To systematically evaluate the efficacy of different treatments after non-curative endoscopic resection for superficial esophageal carcinoma. Methods Databases including PubMed, the Cochrane Library, Embase, China National Knowledge Infrastructure (CNKI) and Wanfang Data were searched from inception to 25 November 2025. The meta-analysis was performed using Review Manager version 5.3, with Stata version 15 employed for supplementary statistical assessments. Results A total of 13 studies involving 1304 patients were included. The results of the meta-analysis showed that the recurrence rate after non-curative endoscopic resection of superficial esophageal carcinoma was significantly higher in the observation group than in the adjuvant treatment group (OR=3.25,95%CI:1.88-5.62,P < 0.0001). However, there was no significant difference in recurrence rate between the chemoradiotherapy group and the surgery group (OR=0.65,95%CI: 0.23-1.84,P =0.42). Patients with lymphovascular invasion had a higher recurrence rate, which was statistically significant (OR=4.01,95%CI:1.48-10.84,P =0.006). Conclusion Lymphovascular invasion is a risk factor for recurrence in patients. The adjuvant treatment group shows significantly reduced recurrence rates compared to the observation group, with no significant difference in recurrence rates between surgical and chemoradiotherapeutic approaches.
Keywords: Esophageal carcinoma, Meta-analysis, Non-curative endoscopic resection, Radiotherapy, Surgery
Received: 20 Sep 2025; Accepted: 27 Nov 2025.
Copyright: © 2025 Wang, Peng and Tian. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Shuni Tian
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.