CASE REPORT article
Front. Oncol.
Sec. Gastrointestinal Cancers: Colorectal Cancer
This article is part of the Research TopicPrecision Medicine and Targeted Therapies in Gastrointestinal and Genitourinary Solid TumorsView all 22 articles
Case report: T-Dxd plus bevacizumab in a Patient with brain metastases from rectal cancer with HER2 amplification
Provisionally accepted
- 1Shenshan Medical Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Shanwei, China
- 2Sun Yat-Sen Memorial Hospital, Guangzhou, China
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Brain metastasis from colorectal cancer was more common in patients with HER2 amplification. Here, we document a 53-year-old male with HER2-amplified rectal cancer and brain metastases, treated with Trastuzumab Deruxtecan (T-Dxd, 5.4 mg/kg) plus bevacizumab (7.5 mg/kg) every three weeks as third line therapy. The patient achieved a partial response with a progression-free-survival of 7 months, highlighting the potential of T-Dxd. Adverse events included grade 3 thrombocytopenia, grade 2 neutropenia, and grade 1 fatigue. Our report emphasizes the rarity of brain metastases in colorectal cancer and illustrates a favorable response to T-Dxd plus bevacizumab.
Keywords: colorectal camcer, brain metastasis, HER2, T-DXd, bevacizumab
Received: 16 Oct 2025; Accepted: 19 Nov 2025.
Copyright: © 2025 JIA, Li, Chen, Wu, Zeng and QIN. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yinduo Zeng, dorazyd@126.com
TAO QIN, qint6@mail.sysu.edu.cn
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