CASE REPORT article
Front. Oncol.
Sec. Cancer Immunity and Immunotherapy
This article is part of the Research TopicAdvancing Surgical Outcomes for Retroperitoneal TumorsView all 6 articles
Eribulin and Sintilimab combined with radiotherapy in a heavily pretreated patient with advanced retroperitoneal myxoid pleomorphic liposarcoma: a case report and literature review
Provisionally accepted
- 1West China Hospital of Sichuan University, Chengdu, China
- 2Sichuan University, Chengdu, China
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Myxoid pleomorphic liposarcoma (MPLPS) is an ultra-rare subtype of soft tissue sarcoma. The limited number of reported cases has led to significant challenges in its clinical management. Here, we present the case of a 52-year-old woman diagnosed with advanced retroperitoneal MPLPS. As first-line therapy, she underwent 4 cycles of chemotherapy with doxorubicin and ifosfamide. Anlotinib was subsequently added to the first-line regimen. Following this, she received gemcitabine plus albumin paclitaxel as second-line therapy. Notably, a partial response (PR) was achieved and sustained for 12 months following the administration of eribulin and sintilimab combined with radiotherapy. The demonstrated effectiveness of this multidisciplinary approach underscores its potential as a novel treatment strategy for patients with advanced MPLPS. To our knowledge, this article represents the first detailed documentation of multidisciplinary diagnosis and treatment of MPLPS.
Keywords: Myxoid pleomorphic liposarcoma, eribulin, PD-1 inhibitor, Pathology, partial response
Received: 06 Oct 2025; Accepted: 24 Nov 2025.
Copyright: © 2025 Zhuo, Li, Fu, Zhang, He, Xu, Liu, Jiang and Deng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yaotiao Deng
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