ORIGINAL RESEARCH article
Front. Oncol.
Sec. Hematologic Malignancies
Trends in Mortality Rates Associated with Multiple Myeloma in the United States, 1999–2023
Provisionally accepted
- Peking University First Hospital, Beijing, China
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Despite major therapeutic progress, multiple myeloma (MM) remains a significant cause of cancer-related death. Using CDC WONDER data from 1999–2023, we analyzed MM mortality among U.S. adults aged ≥25 years. Age-adjusted mortality rates (AAMRs) were standardized to the 2000 U.S. population, and temporal trends were assessed with Joinpoint regression to estimate annual percent changes (APCs). Overall, MM mortality declined nationally; most age groups under 85 years showed significant decreases, while adults ≥85 years experienced modest increases (APC = +0.67; 95% CI, 0.48–0.86). Males consistently had higher AAMRs than females, though both declined. Persistent disparities were evident across race/ethnicity, state, and urbanization levels, with notable geographic heterogeneity—some states (e.g., New York, Ohio, Kansas) demonstrated accelerated recent declines. In summary, MM mortality in the U.S. has improved overall but remains unevenly distributed. Targeted efforts are needed to address demographic and regional inequities and to ensure equitable access to effective MM therapies.
Keywords: Multiple Myeloma, mortality trends, CDC WONDER, Age-adjusted mortality rate, USA
Received: 30 Oct 2025; Accepted: 27 Nov 2025.
Copyright: © 2025 jiang, Liang and Cao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yongping Cao
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