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CASE REPORT article

Front. Oral Health

Sec. Oral Cancers

Volume 6 - 2025 | doi: 10.3389/froh.2025.1548291

This article is part of the Research TopicOral Neoplasms in Children and Young AdultsView all articles

Congenital Granular Cell Epulis in a Neonate: A Case Report and Review of Diagnosis, Treatment, and Prognosis

Provisionally accepted
Placido Carlo GuidonePlacido Carlo Guidone1Roberta SecciaRoberta Seccia2Lelio Adelchi FabrociniLelio Adelchi Fabrocini1Giuseppe TroianoGiuseppe Troiano2Gianfranco MaffeiGianfranco Maffei3Maria Carmela PedicilloMaria Carmela Pedicillo2Giuseppe PannoneGiuseppe Pannone2Lorenzo Lo MuzioLorenzo Lo Muzio2Rosanna ZampareseRosanna Zamparese4Giorgio MoriGiorgio Mori2Ilenia Sara De StefanoIlenia Sara De Stefano2*
  • 1Department of Oral Surgery , Policlinico Riuniti Foggia, Foggia, Italy
  • 2Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Apulia, Italy
  • 3Neonatology end Neonatal Intensive Care Unit, Policlinico Riuniti Foggia,, Foggia, Italy
  • 4Legal Medicine Unit, Ascoli Piceno Hospital C.G. Mazzoni, Ascoli Piceno, Italy

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Abstract Congenital granular cell epulis (CGCE) is a rare benign tumor typically presenting at birth and most commonly located on the maxillary alveolar ridge.Case PresentationWe report the case of a five-day-old female with a smooth, multilobulated mass on the right maxillary alveolar ridge causing feeding difficulties. Surgical excision was performed under sedation. Histological and immunohistochemical analysis confirmed the diagnosis of CGCE. No recurrence was observed at one-month follow-up.ConclusionEarly diagnosis and surgical treatment of CGCE are essential to avoid functional impairment. The prognosis is excellent following complete excision.

Keywords: Benign tumors, Congenital epulis, Granular Cell Tumor, infancy tumor, Oral tumor, histopathology, Immunohistochemistry

Received: 19 Dec 2024; Accepted: 26 Jun 2025.

Copyright: © 2025 Guidone, Seccia, Fabrocini, Troiano, Maffei, Pedicillo, Pannone, Lo Muzio, Zamparese, Mori and De Stefano. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Ilenia Sara De Stefano, Department of Clinical and Experimental Medicine, University of Foggia, Foggia, 71121, Apulia, Italy

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