SYSTEMATIC REVIEW article
Front. Oral Health
Sec. Oral Health Promotion
Volume 6 - 2025 | doi: 10.3389/froh.2025.1550127
This article is part of the Research TopicAdvances in Understanding and Managing Dentine Hypersensitivity and Tooth WearView all 3 articles
Comparison of the effectiveness of diode laser, fluoride varnish and their combination in treatment of dentin hypersensitivity: A Systematic review of randomized clinical trials
Provisionally accepted
- 1Student Research Committee, Baqiyatallah University of Medical Sciences, Tehran, Iran
- 2Department of Psychiatry, Alborz University of Medical Sciences, Karaj, Iran, Karaj, Alborz, Iran
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Dentin hypersensitivity (DH) has long been a challenging condition, with many treatment methods showing limited success. However, the emergence of laser therapy, particularly the significant potential of diode laser (DL) and fluoride varnish, has sparked new hope. This research is a significant step towards a more effective treatment for DH, aiming to evaluate the promising potential of DL in treating DH, both independently and in combination with fluoride varnish. By delving into this research, you are investing your time in understanding a crucial advancement in the field of dentistry.A comprehensive search was conducted across PubMed, Scopus, and Web of Science databases, including studies published up until May 2024. Randomized clinical trials that assessed DH using a Visual Analog Scale (VAS) score were included. Data on participant demographics, treatment types, and VAS scores were extracted by two reviewers. The risk of bias was assessed using the revised Cochrane risk-of-bias instrument for randomized trials (RoB-2).Three studies met the inclusion criteria, comparing NaF varnish, DL, and their combination. Both DL and the combination of DL and NaF varnish were more effective than NaF varnish alone in reducing DH. The combined treatment showed marginally superior outcomes compared to DL alone. Significant reductions in DH were observed across all treatment groups, with the combination therapy demonstrating the most substantial and consistent improvement.Diode laser therapy, particularly when combined with NaF varnish, represents a promising treatment approach for DH, offering superior efficacy over NaF varnish alone. These findings suggest that combination therapy may provide longer-lasting relief, with implications for improving clinical outcomes in DH management.
Keywords: Dentin hypersensitivity, Diode laser, Fluoride varnish, systematic review, Randomized Clinical Trial
Received: 22 Dec 2024; Accepted: 14 May 2025.
Copyright: © 2025 Jalouti, Mohammadian, Yazdanian, Keikha and Hajisadeghi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Nima Jalouti, Student Research Committee, Baqiyatallah University of Medical Sciences, Tehran, Iran
Samira Hajisadeghi, Student Research Committee, Baqiyatallah University of Medical Sciences, Tehran, Iran
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