ORIGINAL RESEARCH article
Front. Oral Health
Sec. Oral Health Promotion
Volume 6 - 2025 | doi: 10.3389/froh.2025.1561781
This article is part of the Research TopicGenetic and Environmental Interactions in Oral Disease: Advancing Diagnostic and Therapeutic StrategiesView all 4 articles
Investigating the Impact of Polymorphisms in ANKK1 and DRD2 Genes on Oral-Related Quality of Life in Males with Temporomandibular Disorders
Provisionally accepted
Samantha Schaffer Pugsley Baratto1
Allan Abuabara2Débora Cristina Cardozo Bueno3Thalita de Paris Matos3Camila Paiva Perin3Gisele Maria Correr Nolasco4
Cesar Lepri5Christian Kirschneck6
Flares Baratto-Filho2,3
Erika Küchler6*- 1University Center UniDomBosco, Curitiba, Brazil
- 2University from the Joinville Region, Joinville, Brazil
- 3University of Tuiuti do Paraná, Curitiba, Parana, Brazil
- 4Federal University of Paraná, Curitiba, Paraná, Brazil
- 5University of Uberaba, Uberaba, Minas Gerais, Brazil
- 6University of Bonn, Bonn, North Rhine-Westphalia, Germany
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Previous studies have reported that genetic polymorphisms may impact the signs and symptoms of temporomandibular disorder (TMD). Therefore, this study aimed to investigate the association between polymorphisms in ANKK1 and DRD2 genes and oral-related quality of life of males with TMD. This cross-sectional study included construction workers with at least one sign or symptom of TMD. The reduced version of the Oral Health Impact Profile questionnaire (OHIP-14) was used to assess oral-related quality of life. Genomic DNA was used to genotype genetic polymorphisms in the locus 11q22-q23: one in ANKK1 (rs1800497) and two in DRD2 (rs6275 and rs6276) using real-time polymerase chain reaction. The scores of the total OHIP-14 and of each domain were compared among the genotypes using Kruskal-Wallis and Dunn’s test in the genotypic co-dominant model. Mann-Whitney test was used in the recessive model (alpha=0.05). The sample included a total of 114 male patients. OHIP-14 total score ranged from 0 to 33. Chronic pain (87.7%), followed by disc displacement (38.2%) were the most common signs and symptoms observed. All the genetic polymorphisms assessed were within the Hardy-Weinberg equilibrium. The domain 'Handicap' (D6) was statistically associated with the genetic polymorphism rs1800497 in ANKK1 (p=0.008). The genetic polymorphism rs1800497 Taq1A in DRD2/ANKK1 was associated with oral health-related quality of life handicap domain in males with TMD. This study showed that genetic polymorphisms can contribute to negative impact on oral health-related quality of life handicap domain. The physical and emotional conditions, together with biological pathways, should receive more attention in the future studies and personalized treatment plans in order to improve the patients' quality of life.
Keywords: Quality of Life, Genes, Pain, Temporomandibular Joint Disorders, Oral Health
Received: 16 Jan 2025; Accepted: 27 May 2025.
Copyright: © 2025 Schaffer Pugsley Baratto, Abuabara, Cardozo Bueno, Matos, Paiva Perin, Correr Nolasco, Lepri, Kirschneck, Baratto-Filho and Küchler. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Erika Küchler, University of Bonn, Bonn, D-53012, North Rhine-Westphalia, Germany
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