ORIGINAL RESEARCH article
Front. Oral Health
Sec. Oral and Maxillofacial Surgery
Volume 6 - 2025 | doi: 10.3389/froh.2025.1630504
This article is part of the Research TopicCurrent Trends in Oral Surgery and ImplantologyView all articles
Effect of Two Deproteinized Bone Graft Materials for Socket Preservation: A Clinical and Histological Study
Provisionally accepted
- Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia
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Objective: To evaluate dimensional changes and new bone formation using two deproteinized bovine bone minerals, NuOss and Bio-Oss, in socket preservation. Materials and Methods: Eighteen patients (6 males, 12 females; aged 23-45 years) requiring posterior tooth extraction were enrolled. Eighteen extraction sockets were augmented with either NuOss or Bio-Oss and covered with a collagen membrane. After six months, Cone Beam Cephalometry (CBCT) assessed dimensional changes in buccolingual width and buccal bone thickness. Bone core biopsies were obtained during implant placement and decalcified for histomorphologic examination. Statistical analysis compared dimensional changes and histomorphometric parameters between groups.Results: All experimental sites healed uneventfully, with complete soft tissue healing within four weeks and successful implant placement. CBCT scans showed comparable, non-significant dimensional reductions. Histomorphologic examination revealed lamellar cortical bone and osteoid trabeculae with partial to optimal integration. NuOss demonstrated significantly higher new bone formation (52.5±2.5%) compared to Bio-Oss (37.5±2.5%; p=0.0021), with lower residual graft material (27.5±2.5% vs. 42.5±2.5%; p=0.0018). Bio-Oss grafted cases exhibited more pronounced inflammatory cell infiltration. Soft tissue proportions were similar between groups (NuOss: 22.5±2.5%, Bio-Oss: 17.5±2.5%; p=0.0892).Conclusion: Both NuOss and Bio-Oss showed positive bone regeneration effects. However, NuOss demonstrated more favorable biocompatibility, with less inflammation and improved bone integration than Bio-Oss.Clinical Relevance: Socket preservation using deproteinized bovine bone minerals (NuOss and Bio-Oss) effectively maintains alveolar ridge dimensions, supporting future implant placement.NuOss demonstrated better biocompatibility indicated by reduced inflammation and osteoclastic activity. These findings can guide clinicians in selecting the most suitable graft material for optimizing bone regeneration outcomes according to their treatment plan.
Keywords: Bio-Oss, NuOss, deproteinized bone graft, Socket preservation, CBCT, Histological findings
Received: 17 May 2025; Accepted: 24 Jun 2025.
Copyright: © 2025 Madi, Al-Naief and Alagl. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Marwa Madi, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia
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