Editorial: Diagnosis and Therapeutic Interventions for Oral Diseases Charting a New Era in Precision Oral Healthcare

Subhabrata Maiti^1,2*Artak Heboyan^3,4

• ¹Saveetha Dental College And Hospitals, Chennai, India
• ²SIMATS Deemed University Saveetha Dental College, Chennai, India
• ³Department of Research Analytics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University,, Chennai, India
• ⁴Yerevan State Medical University Named after Mkhitar Heratsi, Yerevan, Armenia

The improvement of diagnostic accuracy is a recurring theme throughout this Topic. Clinicians can now identify disease processes at earlier and more subtle stages, improving prognosis and enabling more targeted treatments. In Signs and symptoms of oral candidiasis associated with health factors and resistant Candida infections in a Northern Ontario patient cohort, the authors investigate the interplay between host health determinants and antifungal resistance patterns. Their findings highlight how local epidemiological and health factors shape infection profiles, emphasizing the clinical need for surveillance and personalized antifungal strategies.At the molecular level, Whole-genome amplification as a tool to improve bacterial detection by PCR in microbiological samples after endodontic treatment demonstrates the utility of enhanced genomic amplification in increasing the sensitivity of bacterial detection. This approach refines microbiological diagnostics in endodontics, revealing subclinical bacterial persistence that could otherwise escape detection using standard PCR techniques. Such advancements align directly with the broader trend toward biologically informed, precision diagnostics in oral healthcare.Complementing these developments, Role of transcriptomics in the study of oral cancer highlights the transformative role of transcriptomic profiling in identifying key molecular drivers of malignancy. By delineating gene expression patterns associated with oral carcinogenesis, this work reinforces the importance of integrating omics data into both risk assessment and therapeutic design, establishing a foundation for future precision oncology applications within dentistry. While diagnostic technology defines the first frontier of precision dentistry, equally significant progress is evident in therapeutic development. The case report Rescuing a "hopeless" tooth with severe internal resorption during orthodontic therapy presents a compelling example of individualized clinical management. Through coordinated interdisciplinary care, the authors demonstrate that even teeth once considered non-restorable may be salvaged when biologically informed decision-making and contemporary endodontic materials are employed. This case exemplifies how precision treatment planning, supported by advanced imaging and biomaterials, can redefine clinical expectations.Therapeutic research also extends into the domain of host-pathogen modulation. In Effects of combined cyclosporin and azithromycin treatment on human mononuclear cells under lipopolysaccharide challenge, investigators explore the immunomodulatory potential of combined pharmacologic therapy. Their study reveals synergistic effects on inflammatory responses, suggesting new avenues for managing oral and systemic inflammatory conditions. This work underscores the growing importance of translational research that bridges immunology and oral medicine, expanding the therapeutic toolkit beyond traditional antimicrobial strategies. Taken together, these findings depict an evolving landscape where therapeutic innovation and diagnostic precision are increasingly interconnected. Collectively, they highlight the emergence of a new paradigm in oral healthcare that emphasizes biological individuality, early detection, and prevention. This Topic illustrates the scope and complexity of contemporary scientific research in oral medicine-from the genetic characterization of infectious and neoplastic diseases to the regeneration of damaged tissues and the optimization of immune responses.The focus on translational relevance is equally important. Each study demonstrates how laboratory discoveries can evolve into practical tools and procedures for clinicians, bridging the gap between bench research and clinical practice. The research in this collection exemplifies the real-world application of innovation to patient care, whether through enhancing diagnostic precision, improving antimicrobial stewardship, or reframing clinical decision-making. The contributions to "Diagnosis and Therapeutic Interventions for Oral Diseases" collectively affirm that the future of oral healthcare lies in integration-across technologies, disciplines, and biological systems. These studies demonstrate how tailored therapies and precision diagnostics can work synergistically to enhance patient outcomes from molecular, cellular, and clinical perspectives. As dentistry moves toward a more predictive and personalized model, ongoing collaboration among researchers, clinicians, and educators will be essential to ensure that innovation translates into accessible, patient-centered care.The next generation of precision oral healthcare will be defined by the convergence of diagnostics and therapeutics, and this Research Topic serves as both a snapshot of current advancements and a foundation for future exploration.