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REVIEW article

Front. Pharmacol., 23 May 2023
Sec. Renal Pharmacology
This article is part of the Research Topic Advancements in the Management of Cardio-Renal Syndrome: Pioneering Treatments and Therapeutic Breakthroughs View all 5 articles

A comprehensive review of acute cardio-renal syndrome: need for novel biomarkers

Abhi Dutta,Abhi Dutta1,2Shubham Saha,Shubham Saha1,2Ajay BahlAjay Bahl3Anupam Mittal
Anupam Mittal4*Trayambak Basak,
Trayambak Basak1,2*
  • 1School of Biosciences and Bioengineering, Indian Institute of Technology (IIT)-Mandi, Mandi, Himachal Pradesh, India
  • 2BioX Center, Indian Institute of Technology (IIT)-Mandi, Mandi, Himachal Pradesh, India
  • 3Department of Cardiology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
  • 4Department of Translational and Regenerative Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India

Cardiorenal syndrome represents a wide-spectrum disorder involving the heart and kidneys as the primary affected organs. India has an increasingly high burden of acute CRS, coinciding with the rise in global statistics. Up to 2022, approximately 46.1% of all cardiorenal patients have been diagnosed with acute CRS in India. Acute CRS involves a sudden deterioration of kidney functionalities, referred to as acute kidney injury (AKI) in acute heart failure patients. The pathophysiology of CRS involves hyperactivation of the sympathetic nervous system (SNS) and the renin-angiotensin-aldosterone system (RAAS) following acute myocardial stress. The pathological phenotype of acute CRS is associated with perturbed inflammatory, cellular, and neurohormonal markers in circulation. These complications increase the risk of mortality in clinically diagnosed acute CRS patients, making it a worldwide healthcare burden. Hence, effective diagnosis and early prevention are crucial to prevent the progression of CRS in AHF patients. Present biomarkers, such as serum creatinine (sCr), cystatin C (CysC), glomerular filtration rate (GFR), blood urea nitrogen (BUN), serum and/or urine neutrophil gelatinase-associated lipocalin (NGAL), B-type natriuretic peptide (BNP), and NT-proBNP, are clinically used to diagnose AKI stages in CRS patients but are limitedly sensitive to the early detection of the pathology. Therefore, the need for protein biomarkers is emerging for early intervention in CRS progression. Here, we summarized the cardio-renal nexus in acute CRS, with an emphasis on the present clinicopathological biomarkers and their limitations. The objective of this review is to highlight the need for novel proteomic biomarkers that will curb the burgeoning concern and direct future research trials.

1 Introduction

Inter-organ cross-talks are fundamental to the healthy physiological functioning of the body, wherein pathological injury to one organ can cause the acute or chronic dysfunction of another. The heart and kidney reciprocally influence one another through diverse hemodynamic and non-hemodynamic pathways necessary for cardiovascular homeostasis. A maladaptive physiological nexus between the heart and kidneys has recently been characterized as cardio-renal syndrome (CRS) (Costanzo, 2020). The bidirectional overlap of cardiac and kidney disorders caused by one damaged primary organ is broadly described to be multifactorial (Ronco et al., 2008). The National Heart, Lung, and Blood Institute attempted the first definition of the umbrella term CRS in 2004: “the result of interactions between the kidneys and other circulatory compartments that increase circulating volume, exacerbating symptoms of heart failure (HF) and disease progression” (Ronco et al., 2010). However, following this, in the 2008 Acute Dialysis Quality Initiative (ADQI) consensus, Ronco et al. broadly classified CRS into five subtypes mostly based on the primary organ dysfunctioning and the acute or chronic nature of events (Ronco et al., 2008). Type 1 or acute CRS is the rapid progression of acute kidney injury (AKI) or dysfunction in the setting of acute heart failure (AHF). Type 2 or chronic CRS is chronic heart failure underlining the development of chronic kidney disease (CKD). CRS types 3 and 4 are considered reno-cardiac syndromes, caused by acute and chronic kidney dysfunction underlying adverse cardiovascular pathologies such AHF and chronic heart failure (CHF), respectively. In type 5 CRS, systemic diseases such as amyloidosis, sepsis, and cirrhosis cause failing heart and kidney functionalities (Rangaswami et al., 2019). The reported incidence of CRS varies significantly among different subtypes and also among different age groups. AKI is the most prevalent and occurs in a large fraction of clinical acute decompensated heart failure (ADHF) or heart failure (HF) patients (Bagshaw et al., 2010; Hoste et al., 2018). Kidney dysfunctionality in AHF patients is associated with higher mortality and morbidity. AKI is defined and staged by three different concurrent groups, i.e., RIFLE (risk, injury, failure, loss of kidney function, and end-stage kidney disease), AKIN (acute kidney injury network), and KDIGO (kidney disease: improving global outcomes) are widely used (Roy et al., 2013). These variable diagnosis criteria for AKI limit the early diagnosis of CRS. However, despite variable diagnosis patterns, patients hospitalized with ADHF or acute coronary syndrome (ACS) and with varied comorbid conditions showed 20%–75% and 3%–43% incidences, respectively, of developing CRS type 1, accelerating the morbidity (Bagshaw et al., 2010; Fernando et al., 2021). AKI is also one of the strongest risk factors among cardiac surgery patients, with a prevalence of 22.3% (95% CI 19.8–25.1), and is associated with adverse outcomes (Hoste et al., 2018). Increased mortality in cardiac surgery patients is further associated with renal dysfunctionalities requiring dialysis (Mishra et al., 2005). In a recent study, ∼25% of all patients admitted with ADHF developed kidney dysfunctionalities that occurred secondary to the cardiac onset (Hoste et al., 2018). Interestingly, acute CRS is prevalent (∼16%) in patients admitted with AKI (Seckinger et al., 2022).

Acute CRS is the most prevalent form worldwide with an incidence rate of 27%–50% among all CRS types, albeit supported by a limited number of clinical studies (Gigante et al., 2014; Hu et al., 2016; Uduman, 2018; Prothasis et al., 2020), and is associated with increased detrimental outcomes in CRS patients (Gigante et al., 2014). In a prospective cohort study in India, children hospitalized with CRS showed a 40.3% incidence of the acute form of CRS, the highest among all types (Athwani et al., 2017). CRS (both acute and chronic) accounts for the highest mortality among patients admitted with either HF or CKD or CRS (Halimi et al., 2022), thus demanding a proper early diagnosis. Moreover, clinical reports suggest increased mortality in patients admitted with acute CRS compared to that of patients with only cardiovascular dysfunctionalities such as AHF or ADHF, indicating progression time as a risk factor (Ronco et al., 2010; Shirakabe et al., 2013). Another critical factor in acute CRS patients is the onset timing of AKI. Early onset is associated with a higher rate of hospitalisation, whereas the proportion of hospitalized patients with late onset AKI is significantly lower (Di Lullo et al., 2017). Recent studies reported that in-hospital mortality of early AKI patients, i.e., patients having or developing AKI within 5 days of admission, is 13.8% compared to 11.8% in those who developed AKI at a later stage (Shirakabe et al., 2013).

To date, multiple studies have reported the prevalence, risk factors, and outcomes of CRS. However, an increasing trend of acute CRS as the common cause of adverse outcomes and mortality among ADHF and ACS patients has been reported worldwide (Bagshaw et al., 2010; Fernando et al., 2021). Particularly, there is an alarming rise in the diagnosis of acute CRS in India. Hence, it is critical to understand not only the prevalence or overall burden but also the evaluation of clinical outcomes and diagnostic biomarkers to recognize important research gaps for on-time diagnosis and therapeutics of acute CRS patients. In this review, we summarized the prevalence, clinical outcomes, association, and prospects of protein biomarkers for predicting acute CRS with special reference to the Indian population.

2 Prevalence of acute CRS (type 1)

The common onset of acute CRS involves acute decompensated heart failure (ADHF), cardiac surgery (CS), and acute coronary syndrome (ACS) associated with impaired renal function. Patients admitted with ADHF developing either AKI or worsening renal function (WRF) have a five times higher mortality risk (Vandenberghe et al., 2016). Despite differences in defining AKI and population heterogeneity, ∼25%–33% of ADHF patients develop acute CRS (Roy et al., 2013).

Worldwide, the prevalence of acute CRS in patients admitted with acute heart failure ranges from 10% to 71% across studies, with an average of ∼32% (Figure 1).

FIGURE 1
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FIGURE 1. CRS prevalence in India. Proportion of acute CRS in the Indian population.

In India, a single-centred cross-sectional study evaluating the prevalence of CRS subtypes among CRS patients reported acute CRS to be the most prevalent among CRS patients (Prothasis et al., 2020). Across studies, 41.6% of CRS patients are acute (type 1) in nature among all forms of CRS (Figure 2; Table 1). Of note, hypertension, diabetes mellitus (DM), myocarditis, and CKD are the most common and prevalent risk factors in acute CRS patients in India (Tandon et al., 2013; Prothasis et al., 2020; Reddy et al., 2020) (Figure 3).

FIGURE 2
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FIGURE 2. Burden of CRS in symptomatic patients with acute heart failure worldwide. A consensus study from 2005 to 2020.

FIGURE 3
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FIGURE 3. Gender-based distribution of CRS patients in acute heart failure patients worldwide.

TABLE 1
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TABLE 1. Prevalence of acute CRS among cardio-renal or reno-cardiac patients in India.

3 Pathophysiology of acute CRS

According to a 2008 classification, Ronco et al. (2008) defined CRS type 1 or acute CRS as rapid worsening of cardiac function leading to kidney injury (Ronco et al., 2008). The pathophysiology of CRS is a multifaceted process and is diagnosed generally at late stages. It causes higher mortality compared to heart failure patients without AKI (Damman et al., 2007). Although precise mechanistic insights are lacking, a widely accepted conceptual framework for the development of acute CRS involves hemodynamic and nonhemodynamic connections (Virzi et al., 2014).

3.1 Hemodynamic coupling of heart and kidney

Hemodynamic responses involving multiorgan crosstalk initiated in either the heart or kidney involve activation of the classical renin-angiotensin-aldosterone system (RAAS) and the sympathetic nervous system (SNS) (Braam et al., 2014). The pathogenesis of CRS is multifaceted and involves the activation of hemodynamic signalling, SNS activation, and inflammatory and immune responses, with loss of redox homeostasis (Di Lullo et al., 2017; Rangaswami et al., 2019). Activation of one or another synergistically activates others in a vicious cycle (Bongartz et al., 2004).

The pathophysiological onset of acute CRS is caused by reduced cardiac output (CO) and arterial underfilling (Grodin et al., 2016). In patients with ADHF, static increases in volume overload lead to elevated central venous pressure (CVP). Elevated CVP is directly related to renal dysfunctionalities (Prastaro et al., 2022). Increased CVP leads to depressed renal venous pressure (RVP), creating a low flow state that reduces the blood flow gradient to kidneys and leading to renal hypoperfusion (Bock and Gottlieb, 2010; Prastaro et al., 2022). In patients with reduced cardiac functionalities, the low-flow state occurs due to kidney artery under-filling, resulting in a reduced eGFR (glomerular filtration rate) and reduced renal functionalities, which are associated with higher mortality (Damman et al., 2009; Fu et al., 2021). Reduced renal functionalities account for acute kidney injury (AKI), worsening renal function (WRF), and ischemic injury of glomerular and renal tubules, consequently worsening cardio-renal syndrome. A reduction in GFR leads to increased serum creatinine (sCr) compared to the baseline (≥25%), and is used as a biomarker for all type of CRS.

3.1.1 Renin-Angiotensin-Aldosterone System (RAAS) pathways

Fundamental to a failing heart, activation of neurohormonal pathways is the physiologic response to the injury, and is strongly related to worsened outcomes in terms of mortality or morbidity (Rachwan et al., 2019). One of the pathways prototypical to CRS is the RAAS pathway, which is hyperactivated during the onset of acute CRS (Bongartz et al., 2005). RAAS is widely activated across various tissues, including the myocardium and kidney, and is pivotal in linking a damaged heart with worsening kidney functions (Rachwan et al., 2019; Biegus et al., 2021; Ma et al., 2022). Conventionally, systemic RAAS is critical for the maintenance of systemic or circulatory imbalances. In contrast, non-conventional axes of RAAS are a protective response to tissue injuries (Sharma et al., 2019; Holappa et al., 2020; Karimi et al., 2022). In ADHF, renal hypoperfusion leads to the activation of systemic RAAS response in the kidney. Specialized cells in the juxtaglomerular apparatus release renin, an angiotensin-converting enzyme, in response to decreased RBF and hyperactive SNS (Holappa et al., 2020). Increased plasma renin is associated with Ang-I–mediated release of epinephrine and nor-epinephrine (Ma et al., 2022). Plasma Ang-I is subsequently converted to angiotensin II, which is the crucial effector of the RAAS pathway (Verbrugge et al., 2015; Ma et al., 2022). Ang-II is a potent vasoconstrictor and can induce renal injury. On the other hand, Ang-II also causes oxidative stress and localized inflammatory responses. Activation of renal fibroblast to myofibroblast also causes local tissue inflammation, which further activates the so-called non-conventional or tissue RAAS axis (Long et al., 2004). Ang-II also stimulates aldosterone secretion as a product of the RAAS cascade, and under excessive RAAS activity, the plasma level of aldosterone increases (Weber and Brilla, 1991; Ma et al., 2022). Aldosterone, in accordance with Ang-II, stimulates local inflammation and fibrosis in the kidney and heart (Weber and Brilla, 1991; Long et al., 2004; Holappa et al., 2020). RAAS activation in an HF setting occurs as a compensatory mechanism in response to reduced CO and renal hypoperfusion (Takahama and Kitakaze, 2017). However, at increased plasma renin levels, persistent RAAS activation is also influenced by increased sodium retention and decreased excretion by tubular cells, leading to a reduced estimated eGFR and further worsening of renal injury in acute heart failure (Verbrugge et al., 2015). Continued overactivity of RAAS and SNS is counterproductive and leads to additional heart dysfunction due to heightened levels of oxidative stress, inflammation, and fibrotic ECM remodelling (Mentz and O'Connor, 2016). Aldosterone-mediated humoral response induces cardiac inflammation, remodelling, and fibrotic conditions, all leading to HF (Verbrugge et al., 2015; Takahama and Kitakaze, 2017; Ma et al., 2022). In the kidney, RAAS hyperactivation causes pathologic injury through vasoconstriction, inflammation, and fibrosis (Rajapakse et al., 2008; Takahama and Kitakaze, 2017). Moreover, aldosterone induces the production of reactive oxygen species (ROS) in tissues and further exacerbates the inflammatory response and cellular injury to both the heart and kidney (Ma et al., 2022). Thus, reduced CO, RBF, and renal glomerular-tubular feedback loop create a vicious cycle involving RAAS as a central player in hemodynamic disorders (summarized in Figure 4).

FIGURE 4
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FIGURE 4. Overview of the pathophysiological mechanism of CRS in the setting of acute heart failure. In AHF patients, reduced CO causes renal hypoperfusion and subsequent activation of the renin-angiotensin-aldosterone system (RAAS). As a countermeasure, activation of the sympathetic nervous system (SNS) alongside RAAS enhances the systemic and local inflammatory response. Acute injury to both the heart and kidney releases a spectrum of molecules to circulation, designated as CRS biomarkers. CRS biomarkers from the heart include cardiac troponin (cTn) T or I, natriuretic peptide type-B (BNP), N-terminal proBNP, soluble ST2 (suppression of tumorigenicity 2), galectin-3, and hepcidin. Kidney injury biomarkers for CRS include serum NGAL, KIM-1, and NAG. A reduced GFR and impaired renal function contribute to the release of certain molecules into urine and this serves as an indicator of AKI. Such urinary biomarkers include urinary NGAL, collagen I to VI, KIM-1, cystatin-C, IGFBP7, galectin-3, and TIMP2.

3.1.2 Natriuretic peptide system (NPS)

The natriuretic peptide system (NPS) and RAAS function as opposing regulators in maintaining kidney and cardiovascular homeostasis (Peoples et al., 2019). The paracrine effect of RAAS and NPS is also associated with salt and water homeostasis through the kidney (Peoples et al., 2019; Shi et al., 2022). Three natriuretic peptides central to the NPS, atrial (ANP), and brain (BNP), as well as another non-natriuretic protein C-type natriuretic peptide (CNP), act as counter-regulators to the RAAS activities (Ronco et al., 2012a; Peoples et al., 2019). ANP and BNP act as diuretics that promote cardiac fibrosis in HF patients. Neprilysin is a widely distributed membrane-bound endopeptidase that degrades circulatory vasoactive peptides, such as ANP and BNP, and increases end-systolic blood pressure (Ames et al., 2019). However, contradictory to this effect, neprilysin also deactivates the RAAS pathway products Ang-I, Ang-II, and endothelin 1. Accordingly, patients with HF having upregulated soluble neprilysin and animal models of HF have shown enhanced renal neprilysin activity (Charniot et al., 2008; Junho et al., 2022). Moreover, elevated soluble neprilysin in serum is significantly correlated with adverse outcomes and is a good predictor of cardiovascular-related mortalities in HF patients (Charniot et al., 2008).

3.2 Non-hemodynamic coupling of the heart and kidney

3.2.1 Oxidative stress

In healthy physiological conditions, ROS is produced in a balanced manner in every organ, including the heart and kidneys, for cellular functionalities (Milkovic et al., 2019; Peoples et al., 2019). However, under various pathological or physiological stress conditions, secondary and neurohormonal stimulation incurs a loss of oxidative reaction homeostasis, leading to increased production of ROS molecules by mitochondria, causing tissue damage (Shi et al., 2022). Impaired mitochondrial metabolism in the cardiomyocyte and kidney tubular cells is the final common pathway to tissue injury in CRS patients (Ronco et al., 2012a; Shi et al., 2022). Increased oxidative stress and RAAS activity in kidney tubular cells are responsible for water and sodium retention, leading to vasoconstriction and increased SNS activity (Ames et al., 2019). Hyperactive RAAS and SNS are central to the pathogenesis of acute CRS (Rangaswami et al., 2019).

In cardiomyocytes, xanthine oxidase, peroxisomes, xanthine, and NOS enzymes are the major source of ROS and/or RNS (reactive nitrogen species), whereas in the kidney NADPH oxidase (NOX4) is the primary source (Junho et al., 2022). A marked increase in the level of ROS markers is evident in AHF patients (Charniot et al., 2008). Imbalanced ROS and/or RNS levels directly impair the cardiomyocyte physiology and promote inflammatory responses (van der Pol et al., 2019). A gradual loss of cardiomyocytes results from increased oxidative stress, advancing maladaptive myocardial remodelling and fibrosis (Takimoto and Kass, 2007; van der Pol et al., 2019). Association of oxidative stress biomarkers, i.e., plasma aminothiols, cystine, and glutathione, has also shown increased death risk (Patel et al., 2016) and may also be potential biomarkers for CRS patients. Moreover, redox-regulatory protein TRX-1 is elevated in the urinary fraction in AKI and may also serve as an oxidative stress biomarker for kidney injury (Kasuno et al., 2014), but is yet to be tested in CRS patients. Oxidative stress plays a crucial role in developing AKI and is one of the primary aggravating stimuli (Tanaka et al., 2014). However, the functional effects of oxidative stress in CRS pathophysiology are unclear and the lack of suitable biomarkers for CRS patients makes it difficult to diagnose oxidative stress–induced myocardial or kidney injury.

3.2.2 Inflammation

Myocardial ischemia (MI) is one of the primary causes of acute heart failure and is a major comorbidity condition in acute CRS patients (Table 2). Following ischemic injury, reduced circulation volume due to cardiac dysfunctionalities increases the activity of RAAS, SNS, and redox systems in the heart and mediates pathologic inflammation in acute heart failure patients (Riehle and Bauersachs, 2019). Following an ischemic injury in a rat model of MI, increased macrophage infiltration in the kidney and CCR2+-activated monocytes in circulation is evident, suggesting an inflammatory response against the injury (Cho et al., 2013). Angiotensin II (Ang-II) is primarily upregulated in the RAAS pathway and is a major effector in RAAS-mediated inflammatory responses in the NF-κB and AP-1 (Activator protein 1) pathways (Colombo et al., 2012). In acute CRS, hyperactivity of the RAAS axis and inflammation are widely reported (Colombo et al., 2012). Ang-II induction is associated with increased inflammatory cytokine (e.g., TNF-α, IL-6, and IL-1β) production by cardiomyocytes. Likewise, the inflammatory response in the kidney is also suggested to be mediated through the NF-κB pathway (Cho et al., 2013). Moreover, C-reactive protein (CRP), an acute phase inflammatory mediator marker upregulated in AKI, is independently correlated with higher mortality in ADHF patients (Colombo et al., 2012; Kumar et al., 2019). Recently, an association between inflammatory markers and CRS has been explored in HF patients with renal failure (Jensen et al., 2010; Colombo et al., 2012). Such inflammatory mediators associated with AHF or AKI or directly with CRS supposedly play active roles in acute CRS pathogenesis and have prognostic value in CRS patients.

TABLE 2
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TABLE 2. Common aetiologies, gender (%), CRS prevalence, and biomarker levels in patients hospitalised for symptomatic AHF. Ischaemic heart disease (IHD), acute heart failure (AHF), acute decompensated heart failure (ADHF), diabetes mellitus (DM), acute kidney injury (AKI), chronic kidney disease (CKD), coronary artery disease (CAD), myocardial ischemia (MI), heart failure (HF), and acute coronary syndrome (ACS) are the most common comorbidities in acute CRS patients worldwide. Values are the mean ± SD (standard deviation).

3.2.3 Apoptosis

Following MI, kidney tubular cell apoptosis is evident in animal models (Cho et al., 2013). Inflammation-mediated apoptosis is thought to be involved in kidney damage in AKI (Virzi et al., 2012). Incubation with plasma from CRS type I patients strongly induces apoptotic death in monocytes, correlating with the suggested hypotheses of Cho et al. (2013) (Virzi et al., 2012; Cho et al., 2013). Moreover, kidney cell apoptosis is associated with upregulated TNF-α and IL-6 levels (Cho et al., 2013), pointing towards the role of inflammation-mediated pathological apoptosis–induced injury in AKI.

4 Molecular pathophysiology of CRS

Recently, discoveries of novel proteomic biomarkers and miRNAs associated with CRS have allowed new molecular mechanisms to be described. In the acute cardiorenal nexus, inflammatory responses are exaggerated to alleviate primary myocardial injury, which further aggravates injury to both the heart and kidney. CXCR4 is a G protein-coupled chemokine receptor associated with the trafficking of immune cells to injured organs (Chu et al., 2011; Yuan et al., 2015). CXCR4 is the cognate receptor for SDF-1 and helps in aggravating inflammation-induced cardiorenal fibrosis (Chu et al., 2011). In acute ST-segment elevated MI patients, CXCR4 signals after cardiac injury predict adverse outcomes in such patients (Werner et al., 2021). Prolonged CXCR4 expression in renal cell types is also found to be associated with injury-mediated fibrotic response (Yuan et al., 2015; Werner et al., 2021). Hypertension is one of the most common comorbidity aetiologies associated with acute CRS and is associated with neurohormonal RAAS hyperactivation, inflammatory responses, and CRS progression (Chu et al., 2011).

Acute inflammation is strongly linked with cardiorenal fibrosis. Angiotensin II-mediated activation of stromal-derived factor (SDF)-1 is associated with the infiltration of pro-fibrotic immune cells to the site of local inflammation (Chu et al., 2011; Van Linthout et al., 2014). Moreover, neurohormonal or Ang-II stimulation of cardiomyocytes is associated with overexpression of SDF-1 (Chu et al., 2010). Increased levels of SDF-1 interact with CXCR4 and promote fibroblast infiltration during cardiorenal fibrosis (Chu et al., 2010; Chu et al., 2011). The acute inflammatory response in the myocardium is responsible for the release of inflammatory cytokines and chemokines such as TNF-α, IL-6, IL-18, and MCP-1 by the infiltered immune cells (Virzi et al., 2018; Jin et al., 2021). Higher circulating pro-inflammatory cytokine levels are evident in acute CRS patient samples (Virzi et al., 2018). Overexpression of TNF-α, MCP-1, VCAM-1, and ICAM-1 in the renal tissue in CRS is directed towards an inflammatory response in the kidney (Jin et al., 2021). This suggests that aggravated local and systemic inflammatory responses participate in the intra-organ crosstalk, lying at the centre of the pathogenesis of CRS (Jin et al., 2021). In combination with inflammation, a coalition of RAAS and angiotensin type −1 (AT-1) receptor-mediated NF-κB signalling has recently been described (Li and Zhuo, 2008). Even though the distinct mechanism is yet to be studied, pro-inflammatory molecules have emerged as potential marker candidates, due to the association between inflammation and CRS pathophysiology (Figure 5).

FIGURE 5
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FIGURE 5. Molecular mechanism underlying the inflammatory and fibrotic response in CRS pathophysiology. Acute injury to the heart and subsequently to the kidney causes the release of SDF-1 to circulation. Hyperactivation of RAAS induces the SDF-1- CXCR4 interaction and the infiltration of immune and fibrotic cells to local inflammatory sites. This further aggravates inflammation and fibrosis in damaged organs, reducing their functionalities.

5 Clinically available biomarkers for acute CRS

5.1 Serum creatinine

An increased serum creatinine (sCr) level is one of the standard parameters for determining acute CRS compared to other types (I–V) (Gai et al., 2010). AKI is defined by the rise of creatinine in serum, and, even with certain non-specificity, it is a gold standard as of now to predict and diagnose kidney injury (Grynberg et al., 2017). In patients undergoing cardiac surgery, AKI onset is predictable through the rise in sCr from baseline to post-operative day 1 and is associated with longer hospitalisation and significantly increased morbidity (Zappitelli et al., 2009; Ho et al., 2012; Grynberg et al., 2017). The normal level of serum creatinine ranges from 0.6 to 1.2 mg/dL in males and from 0.5 to 1.1 mg/dL in females (Hosten et al., 1990). AKI worsening in hospitalized ADHF patients is strongly correlated with serum creatinine levels; 36% of patients with sCr levels >2.0 mg/dL have worsened AKI after admission (Chen et al., 2016). In the Indian population, sCr is significantly upregulated in CRS patients who have worse clinical outcomes (Reddy et al., 2020).

5.1.1 Limitations

Despite being a significant biomarker of WRF, sCr fails to accurately assess the degree of kidney dysfunctionalities during acute injury-mediated changes (Bellomo et al., 2004). The sCr level is insensitive to minor to moderate changes in GFR and only increases after more than a moderate change in GFR (Murty et al., 2013). Moreover, creatinine is produced in the liver and the sCr levels can be influenced by conditions such as fever, liver-disease, or ageing, which interfere in accurate diagnosis (Bellomo et al., 2004). In the Indian population, sCr is studied as a diagnostic parameter, but considering all these limitations, sCr is less reliable in detecting early AKI in CRS patients (Reddy et al., 2020).

5.2 Blood urea nitrogen (BUN)

Blood urea nitrogen (BUN) is typically used to diagnose AKI in combination with sCr (Edelstein, 2008). Urea in blood is excreted by cells as a metabolic by-product and is freely filtered through glomerulus (Seki et al., 2019). BUN in serum is the nitrogen fraction of urea, which normally ranges between 5 and 20 mg/dL (1.8–7.2 mmol urea/L) (Hosten et al., 1990). An increase in BUN levels indicates declining renal functionalities (Seki et al., 2019). In acute CRS patients, hyper-activation of RAAS, SNS, and the neurohormonal system causes upregulation in BUN and acts as a predictor for kidney functionalities (Qian et al., 2019). An elevated BUN/sCr ratio can predict declining GFR in acute CRS patients.

5.2.1 Limitations

The broad reference range of BUN makes it suboptimal for diagnosing acute CRS. Independent of kidney functionalities, and being a metabolic by-product, BUN is influenced by several nonrenal factors such as dietary protein intake, protein catabolism, high-dose steroid therapies, hepatic urea synthesis, etc., (Yu, 2020). A significantly higher BUN level is strongly associated with unfavourable outcomes among CRS patients in India (Reddy et al., 2020).

5.3 Cystatin C

Cystatin C (CysC) is a 13.3 kDa cysteine protease inhibitor protein synthesized by all nucleated cells. Serum CysC is freely filtered through the glomerulus into urine and is thus considered a parameter in assessing GFR to evaluate renal functioning. Unlike serum creatinine, once in the glomerular filtrate, CysC is not further reabsorbed or secreted directly into the urinary fraction by tubular cells (Laterza et al., 2002). This makes it a more accurate endogenous surrogate marker for GFR than sCr. CysC measurement in ACS patients has improved risk stratification early on admission, making it a promising biomarker for acute CRS (Jernberg et al., 2004).

5.3.1 Limitations

Although CysC is a more accurate predictor of GFR in AKI compared to sCr, factors such as high body fat mass, BMI, diabetes, inflammation, and other disorders like thyroid affect serum CysC levels (Muntner et al., 2008; de Vries and Rabelink, 2013; Gonzalez et al., 2022). Moreover, it has been reported that patients undergoing cardiac surgery had minimal difference in CysC levels (Shlipak et al., 2013). The serum CysC level is affected in AHF patients without renal impairment (Naruse et al., 2009), making it unreliable in diagnosing acute CRS patients. Moreover, older age, male gender, smoking, and higher CRP levels independently regulate the CysC level, irrespective of AKI (Knight et al., 2004). Although CysC is significantly correlated with eGFR and renal dysfunctionalities in different age groups in India, there is still a gap in terms of real world evaluation in CRS patient samples (Kumaresan and Giri, 2011).

5.4 Glomerular filtration rate

The glomerular filtration rate (GFR) is an index of kidney function, measuring the plasma flowing through it during a certain period (e.g., per minute). A decrease in GFR below the baseline of 60 mL/min per 1.73 m2 (Mullens et al., 2009) indicates dysfunctionalities in kidney tubules. Normal or mild renal insufficiency was defined at a GFR of 60 mL/min/1.73 m2 (Mullens et al., 2009). In CRS patients, venous congestion causes under perfusion of the kidney. Kidney hypoperfusion is responsible for impaired GFR and is a strong risk factor for AKI or WRF. Myogenic control over GFR is intrinsically influenced by activated RAAS, SNS, and ROS/NO imbalance during CRS, and causes arterial underfilling in a failing or ischemic heart (Viswanathan and Gilbert, 2010). Moreover hysterical RAAS and neurohumoral over-activation causes vasoconstriction and decreased RBF (Ljungman et al., 1990). Decreased RBF induces renal ischemia in the heart failure setting (Viswanathan and Gilbert, 2010; Rangaswami et al., 2019). Evaluating eGFR at admission somewhat predicts AKI in HF patients. Declining GFR in CRS patients is correlated with in-hospital worsened outcome and increased mortality (Wang et al., 2020). A single centred prospective study in India associated reduced eGFR with non-favourable outcome in-hospital as well as in discharged CRS patients (Reddy et al., 2020).

5.4.1 Limitations

Decongestive measure in AHF patients may complicate proper assessment of eGFR, thus limiting the diagnosis of AKI (Rangaswami et al., 2019). GFR in AKI is measured by evaluating BUN and sCr, which do not always correlate with GFR (Molitoris, 2012). This limits the early detection of AKI due to a misleading GFR calculation. Moreover, inaccuracy in eGFR calculation causes incorrect prediction in respect to worsening AKI (Kirwan et al., 2013); thus, a new standard needs to be set using more accurate biomarkers. Although the eGFR rate is associated with worsened outcomes in CRS patients in India, it needs to be evaluated in a larger cohort of CRS patients (Prothasis et al., 2020).

5.5 Serum and/or urine neutrophil gelatinase-associated lipocalin (NGAL)

NGAL, also known as lipocalin-2 or siderocalin, is a 25 kDa small, glycosylated protein belonging to the lipocalin superfamily, and was initially described to be secreted from granular neutrophils upon specific stimulus (Cowland and Borregaard, 1997; Kokkoris et al., 2012). Human NGAL is a 25-kDa immunoreactive protein secreted by the neutrophils (Bolignano et al., 2008). Kidney tubular cells also secrete NGAL as an acute phase factor to immediately signal a condition on injury (Mishra et al., 2003; Bolignano et al., 2008). NGAL is also secreted at a basal level by cardiomyocytes, kidney tubular cells, and other tissue cells (Cowland and Borregaard, 1997). In ischemic kidney injury or renal toxicity, NGAL is overexpressed in kidney tubular cells as an early post-ischemic response (Kokkoris et al., 2012; Rangaswami et al., 2019; Phan, 2021). In patients with cardiac surgery, serum and urine NGAL levels increased 10-fold or more and were an early biomarker for the onset of AKI (Palazzuoli et al., 2014). Patients hospitalized with ADHF and having higher than baseline NGAL levels were correlated with AKI and mortality (Macdonald et al., 2012). In contrast to traditional sCr, increased NGAL levels are detected 1–3 h after surgery in such patients and are also supported by animal model data (Mishra et al., 2003; Kokkoris et al., 2012). AKI or WRF are diagnosed by RIFLE in 25%–40% of patients admitted with ADHF (Ronco et al., 2012b; Palazzuoli et al., 2014). NGAL measurement at admission is suggested for the early detection of WRF in acute CRS patients, and NGAL levels above 130–170 ng/mL are correlated with adverse clinical outcomes (Alvelos et al., 2011; Palazzuoli et al., 2014).

The relative abundance of monomeric NGAL in AKI patient plasma samples is principally due to secretion by stressed kidney epithelial cells as monomers, which fail to further dimerize. A 100-fold rise in urinary and a 20-fold rise in plasma NGAL levels have allowed prediction of AKI in AHF patients well before any significant change in sCr levels (Martensson and Bellomo, 2014).

5.5.1 Limitations

Although NGAL is widely accepted as an early biomarker for AKI in CRS patients, differences in cut off values and responses in individuals limit its application. However, high-sensitivity assays for plasma NGAL with a series of measurements can increase the sensitivity of the diagnosis of AKI in acute CRS (Ronco et al., 2012b). Combined plasma NGAL, Cystatin C, and NT-proBNP values above basal levels could significantly improve the predictive accuracy of the diagnosis of CRS in ADHF or AHF patients (Phan, 2021; Song et al., 2021). In respect to the Indian CRS cohort, NGAL has not yet been evaluated in any clinical studies, limiting the diagnostic ability of such proteomic markers.

5.6 Brain natriuretic peptide

BNP (B-type natriuretic peptide) is predominantly synthesized by LV cardiomyocytes as a protective mechanism against pressure or volume overload (Cao et al., 2019; Okamoto et al., 2019). BNP mimics ventricular stress by decreasing the kidney tubule vascular resistance and increasing GFR (Okamoto et al., 2019; Sarohi et al., 2022a). However, hyperactivation of RAAS and SNS inhibit the BNP activity and worsens the condition (Okamoto et al., 2019). Human BNP is a 134 amino acid peptide that, under pathological conditions, is rapidly cleaved to form a 108 amino acid sequence, namely, pro-BNP. Pro-BNP is cleaved by furin/corin/proNP convertase to release BNP and NT-pro BNP to circulation (Cao et al., 2019). In patients with AHF or MI, a transient rise occurs in the circulating N-terminal pro-BNP and pro-BNP levels (Breidthardt et al., 2011; Phan Thai et al., 2020). Patients with worsened in-hospital outcomes have elevated levels of plasma pro-BNP compared to surviving CRS patients (Wang et al., 2020). In healthy individuals, the circulating baseline level ranges from 21 to 281 pg/mL in males and 51–240 pg/mL in females (Welsh et al., 2022). An elevated baseline NT-proBNP level is profoundly associated with acute CRS (Sabatine et al., 2004; Chen et al., 2016). Moreover, a drop in serum NT-proBNP increases the chance of survival and is associated with fewer re-hospitalisation events (Gembillo et al., 2021).

5.6.1 Limitations

The circulating NT-proBNP level increases with age and corresponds to age-related health conditions. In elderly individuals with no cardiovascular complications, the NT-proBNP level can hover at a much higher level than the baseline (Welsh et al., 2022), thus limiting its application as a unique protein biomarker for diagnosing CRS. Similar to NGAL, BNP/pro-BNP or NT-pro BNP are yet to be evaluated in clinical CRS patient samples in India.

5.7 Other biomarkers in use

Biomarker investigation across all CRS types has revealed a number of promising biomarkers; however, these are yet to be studied significantly. The serum hepcidin level is presented as being associated with relative thickening of the LV wall (Kim, 2020).

Apart from clinical investigations, a handful of protein biomarkers are repeatedly studied in acute and chronic CRS. Kidney Injury molecule 1 (KIM-1), sST2, Galectin-3, N-acetyl-κ-d glycosaminidase (NAG), liver-type Fatty acid-binding proteins (L-FABP), insulin-like growth factor–binding protein 7 (IGFBP7), and tissue inhibitor of metalloproteinase 2 (TIMP2) are some recent biomarkers that have been studied in terms of CRS (Tan and Sethi, 2014; Rangaswami et al., 2019; Goffredo et al., 2021).

5.7.1 KIM-1

KIM-1 is a transmembrane receptor (type-1) glycoprotein, dispersedly distributed in the epithelial cell surface (Song et al., 2019). It is also found in proximal tubular epithelial cells of the kidney in acute injury conditions (Song et al., 2019). In AKI patients, kidney tubular epithelial cells express KIM-1, which, after injury, are present in the urinary compartment, leading to detection of KIM-1 in urine (Zhang et al., 2007). Recent studies have shown that upregulated KIM-1 expression in chronic CRS patients is in alignment with NGAL (Kaddourah et al., 2016). In AKI, limited and sudden elevation of urinary KIM-1 in AKI makes it an advantageous candidate as a potential biomarker for acute CRS diagnosis (Medic et al., 2015). However, urinary KIM-1 levels were found not to be statistically significant in prognosing acute CRS (Atici et al., 2019). On the other hand, in a recent multicentre prospective study, Chen et al. found KIM-1 to be a valuable predictor of AKI in ADHF patients (Chen et al., 2016). Moreover, the Plasm KIM-1 level was found to be higher in cardiac surgery patients having AKI compared to that in patients without AKI and this was validated against animal smodels (Sabbisetti et al., 2014).

5.7.2 Galectin-3

Galectin-3 (Gal-3) is a 30 kDa β-galactoside-binding lectin involved in cell-cell and cell-ECM interactions. Gal-3 is secreted by injured and inflammatory cells into the serum and is subsequently also found in urine (Hara et al., 2020). In acute heart failure, it has already been described and validated as an early diagnostic biomarker (Hara et al., 2020). Moreover, reduced GFR affects the Gal-3 level in HF patients compared to that in heart dysfunction patients (Podzolkov et al., 2022).

5.7.3 NAG

NAG is a 130 kDa lysosomal enzyme secreted upon the exocytosis or degradation of cells in healthy tissues. Due to its high molecular weight it is not filtered through the glomerulus and its levels are generally low in the urinary compartment (Hashimoto et al., 1995). However, in an injury event or lesion to the nephron, the urinary level of NAG increases abruptly and this signifies AKI(140). The NAG level is found to be upregulated in both AKI and hypertensive patients (Hashimoto et al., 1995; Goffredo et al., 2021) and plays a possible role in the progression of acute CRS.

5.7.4 TIMP-2 and IGFBP7

IGFBP7 (insulin-like growth factor–binding protein 7) and TIMP2 (tissue inhibitor of metalloproteinase 2) are biomarkers of cell cycle arrest. Studies have described upregulated urinary IGFBP7 and TIMP2 levels in early AKI patients, in alignment with NGAL (Sakyi et al., 2021).

Other than these, cardiac Troponin T (cTnT) and cTnI are highly sensitive prognostic and diagnostic biomarkers of AHF/ADHF, which is a potential biomarker of acute CRS. Elevated cardiac troponins are correlated with declining GFR and associated with increased mortality in CKD patients (Colbert et al., 2015; Rangaswami et al., 2019) and needs to be studied in acute CRS also. Inflammatory cytokine tumor necrosis factor alpha-α (TNFα) is reported to be elevated in a cohort of AHF patients and is associated with increased mortality (Dunlay et al., 2008). TNFα and other inflammatory biomarkers, such as IL-6, are potential biomarkers and may be evaluated in acute CRS patients. To date, most clinical studies in India diagnose CRS based on echocardiographic parameters (Tandon et al., 2013; Reddy et al., 2020). Very few biomarkers of CRS are evaluated in the Indian population, limiting early detection of AKI in future CRS patients.

6 Omics in acute CRS

The acute form is highly prevalent among all five CRS subtypes and is associated with increased mortality/severity in AHF/ADHF/ACS and cardiac surgery patients. To date, clinical studies have evaluated diagnostic-based biomarkers. Recently, omics-based approaches were used in a number of studies on urinary or plasma counterparts in CRS patients. Recently, a case–control study by Petra et al. performed a large scale urinary peptidome analysis in CRS patients and analysed peptides and proteins in urine (Petra et al., 2021). The study described 30 protein precursors detected in CRS patients only, which are absent in either HF or CKD patients. This includes several cardiac and renal ECM proteins, including COL4A2, COL4A4, and COL6A5. Other proteins, such as ROBO1, HUWE1, and CD14, are associated with fibrosis and dysfunction of the heart and kidney and are uniquely found in CRS urinary peptidome (Zhu et al., 2020; Liu et al., 2021; Petra et al., 2021; Sarohi et al., 2022b). Moreover, immune response–associated proteins, such as CD14, CD99, and IRF-6, are correlated with a hyperactivated immune response in CRS patients (Rangaswami et al., 2019; Liu et al., 2021). In a rat model of HF, renal proteome analysis showed upregulation of advanced glycosylation product-specific receptor (RAGE), renal angiotensin converting enzyme (ACE), and angiotensin II (Melenovsky et al., 2018). RAGE is a DNA sensor protein that is linked to damage associated molecular pattern (DAMP)–mediated inflammation in HF. This suggests a possible crosstalk between RAGE-immune signalling and ACE-mediated Ang-II signalling in acute CRS progression (Melenovsky et al., 2018). Upregulation of periostin, collagen VI, gal-3, and so on in the HF kidney proteome suggests fibrosis in HF models. Gal-3 is a well-studied HF biomarker associated with worsened outcomes in HF and CKD patients (Melenovsky et al., 2018; Sarohi et al., 2022b).

6.1 miRNA as acute CRS biomarker

miRNAs are endogenously conserved non-coding RNA molecules, associated with post-transcriptional gene regulation (Huang et al., 2020). In humans, thousands of such mRNA have been described and hundreds of them have been reported in body circulation, with reduced susceptibility to degradation (Zhou et al., 2018). miRNAs such as miR-21, miR-208, and miR-320 are varyingly associated with acute CRS (Huang et al., 2020). Interestingly, one such in miRNA abundance, miR-21, is upregulated in the stressed heart and kidney, promoting fibrosis (Kumarswamy et al., 2012; Liu et al., 2016). miR-21 is detected in the urinary compartment in cardiac surgery patients and is also evident in AHF and AKI (Du et al., 2013; Sun and Lerman, 2019). Its pro-fibrotic characteristics have been studied recently as a potential target for CRS diagnosis and therapeutics (Kumarswamy et al., 2012; Huang et al., 2020). As described previously, hypertension is one of the most common comorbidity conditions in acute CRS. miRNA-21, miRNA-93, and miRNA-200b have been found in hypertensive patients (Kwon et al., 2016) and can be evaluated for diagnosis of CRS as well.

7 Challenges in identifying biomarkers

The pathogenesis of CRS lies in reduced cardiac ejection, resulting in increased central venous pressure (CVP). Increased CVP leads to insufficient renal blood flow (RBF) and activates classic hemodynamic mechanisms (Ronco et al., 2012a). However, implications of non-hemodynamic pathways, such as dysfunctional sympathetic nervous system (SNS) activation, persistent renin-angiotensin-aldosterone system (RAAS) activation, and ROS/NO imbalance, exacerbating the inflammatory and immune signalling pathways, are also operative in CRS (Ronco et al., 2012a; Haase et al., 2013). Every nation, including India, uses eGFR, sCr, and BUN as the cornerstone of clinical diagnosis of AKI and CRS in patients with HF. sCr is not an early diagnostic marker for AKI in CRS patients and eGFR is calculated using creatinine levels in serum or urine (Bragadottir et al., 2013). Moreover, the means of assessing eGFR have been poor in terms of early AKI assessment (Bragadottir et al., 2013). Although conclusive studies are lacking, serum and urine NGAL has recently been found to be elevated in early AKI in patients with ADHF. However, non-hemodynamic pathways such as dysfunctional sympathetic nervous system (SNS) activation, persistent renin-angiotensin-aldosterone system (RAAS) activation, and ROS/NO imbalance exacerbating the inflammatory and immune signalling pathways are also operative in CRS (Ronco et al., 2012a; Haase et al., 2013).

8 Need of novel biomarkers

CRS has emerged as a major health issue considering the robust modern-day lifestyle, and is the primary cause of baseline risk factors such as hypertension, diabetes mellitus, coronary artery diseases, and atrial fibrillation (He et al., 2021). Acute HF or CKD patients admitted with such risk factors are correlated with worsened pathophysiologic conditions in CRS patients. The lack of prognostic features leads to delayed diagnosis of the syndrome, further affecting the patient, even if certain kidney injuries or cardiac injury biomarkers are nowadays used for diagnosis of CRS. Biomarkers, such as serum creatinine, used as kidney injury markers, BNP/NT-pro BNP, or cardiac Troponin T levels used for myocardial injury, have several limitations for projecting CRS progression in a chronic setting (Goffredo et al., 2021). However, in recent years, research is growing in terms of assessing biomarkers of AKI, AHF, or CRS for simple and highly predictive biomarker searching. Novel biomarkers such as hepcidin, soluble urokinase-type plasminogen activator receptor (suPAR), placental growth factor (PlGF), urinary podocin/creatinine ratio (UP/Cr), and urinary cofilin-1 have been found in CRS patients (Nakada et al., 2019; Kim, 2020; Nikorowitsch et al., 2020; Gembillo et al., 2021). However, the poor prognostic value of such traditional biomarkers demands novel biomarkers specific to CRS, not only for better prognosis but also for greater understanding of the molecular pathophysiology. Nonetheless, given the wide and overlapping pathophysiological nature of cardiorenal syndrome, high throughput multi-omics, specifically the proteomic approach, holds great potential for improving disease prognosis and management. In this context, a multi-omics–based clinical study for the discovery of CRS specific biomarkers has been recently funded by the Indian Council of Medical Research (ICMR, Government of India). With ongoing efforts for masterful control of the pathological progression of CRS, an omics-based approach is the need of the hour for finding suitable and potential prognostic and diagnostic biomarkers with better sensitivity and specificity.

Author contributions

AD, SS, AB, AM and TB worked on summarizing the recent knowledge about the progression of acute cardio-renal syndrome. AD prepared all the figures and wrote the manuscript. AB and AM overviewed the drafts of the manuscript. TB conceptualized the overall structure of the review and finalized the manuscript. All authors listed have made a substantial, direct, and intellectual contribution to the work and approved it for publication.

Funding

This study on cardiorenal syndrome was funded by an ICMR ad hoc project (RFC No. NCD/Adhoc/207/2022-2023 dated March 11, 2023).

Acknowledgments

ICMR-funded project to AB, AM and TB are acknowledged for this work. The seed grant (IITM/SG/TB/75) from IIT-Mandi to TB is partially acknowledged for this work. AD acknowledges the UGC-JRF fellowship (MHRD, Govt. of India) for their doctoral program.

Conflict of interest

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Publisher’s note

All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.

Abbreviations

ACS, acute coronary syndrome; ADHF, acute decompensated heart failure; AHF, acute heart failure; AKI, acute kidney injury; BUN, blood urea nitrogen; BNP, B-type natriuretic peptide; CO, cardiac output; CRS, Cardiorenal syndrome; CVP, central venous pressure; CysC, cystatin C; eGFR, estimated glomerular filtration rate; ECM, extracellular matrix; HF, heart failure; LV, left ventricle; MI, myocardial infarction; NGAL, neutrophil gelatinase-associated lipocalin; NT-proBNP, N-terminal-proBNP; RAAS, renin-angiotensin-aldosterone system; RBF, renal blood flow; ROS, reactive oxygen species; SNS, sympathetic nervous system; sCr, serum creatinine; WRF, worsening renal function.

References

Alvelos, M., Pimentel, R., Pinho, E., Gomes, A., Lourenco, P., Teles, M. J., et al. (2011). Neutrophil gelatinase-associated lipocalin in the diagnosis of type 1 cardio-renal syndrome in the general ward. Clin. J. Am. Soc. Nephrol. 6 (3), 476–481. doi:10.2215/CJN.06140710

PubMed Abstract | CrossRef Full Text | Google Scholar

Ames, M. K., Atkins, C. E., and Pitt, B. (2019). The renin-angiotensin-aldosterone system and its suppression. J. Vet. Intern Med. 33 (2), 363–382. doi:10.1111/jvim.15454

PubMed Abstract | CrossRef Full Text | Google Scholar

Aronson, D., and Burger, A. J. (2010). The relationship between transient and persistent worsening renal function and mortality in patients with acute decompensated heart failure. J. Card. Fail 16 (7), 541–547. doi:10.1016/j.cardfail.2010.02.001

PubMed Abstract | CrossRef Full Text | Google Scholar

Athwani, V., Bhargava, M., Chanchlani, R., and Mehta, A. J. (2017). Incidence and outcome of acute cardiorenal syndrome in hospitalized children. Indian J. Pediatr. 84 (6), 420–424. doi:10.1007/s12098-017-2307-3

PubMed Abstract | CrossRef Full Text | Google Scholar

Atici, A., Emet, S., Toprak, I. D., Cakmak, R., Akarsu, M., and Tukek, T. (2019). The role of kidney injury molecule-1 in predicting cardiorenal syndrome type 1 after diuretic treatment. Arch. Med. Sci. Atheroscler. Dis. 4, e208–e214. doi:10.5114/amsad.2019.87305

PubMed Abstract | CrossRef Full Text | Google Scholar

Bagshaw, S. M., Cruz, D. N., Aspromonte, N., Daliento, L., Ronco, F., Sheinfeld, G., et al. (2010). Epidemiology of cardio-renal syndromes: Workgroup statements from the 7th ADQI consensus conference. Nephrol. Dial. Transpl. 25 (5), 1406–1416. doi:10.1093/ndt/gfq066

PubMed Abstract | CrossRef Full Text | Google Scholar

Bellomo, R., Kellum, J. A., and Ronco, C. (2004). Defining acute renal failure: Physiological principles. Intensive Care Med. 30 (1), 33–37. doi:10.1007/s00134-003-2078-3

PubMed Abstract | CrossRef Full Text | Google Scholar

Biegus, J., Nawrocka-Millward, S., Zymlinski, R., Fudim, M., Testani, J., Marciniak, D., et al. (2021). Distinct renin/aldosterone activity profiles correlate with renal function, natriuretic response, decongestive ability and prognosis in acute heart failure. Int. J. Cardiol. 345, 54–60. doi:10.1016/j.ijcard.2021.10.149

PubMed Abstract | CrossRef Full Text | Google Scholar

Bock, J. S., and Gottlieb, S. S. (2010). Cardiorenal syndrome: New perspectives. Circulation 121 (23), 2592–2600. doi:10.1161/CIRCULATIONAHA.109.886473

PubMed Abstract | CrossRef Full Text | Google Scholar

Bolignano, D., Donato, V., Coppolino, G., Campo, S., Buemi, A., Lacquaniti, A., et al. (2008). Neutrophil gelatinase-associated lipocalin (NGAL) as a marker of kidney damage. Am. J. Kidney Dis. 52 (3), 595–605. doi:10.1053/j.ajkd.2008.01.020

PubMed Abstract | CrossRef Full Text | Google Scholar

Bongartz, L. G., Cramer, M. J., and Braam, B. (2004). The cardiorenal connection. Hypertension 43 (4), e14. doi:10.1161/01.HYP.0000118521.06245.b8

PubMed Abstract | CrossRef Full Text | Google Scholar

Bongartz, L. G., Cramer, M. J., Doevendans, P. A., Joles, J. A., and Braam, B. (2005). The severe cardiorenal syndrome: 'Guyton revisited. Eur. Heart J. 26 (1), 11–17. doi:10.1093/eurheartj/ehi020

PubMed Abstract | CrossRef Full Text | Google Scholar

Braam, B., Joles, J. A., Danishwar, A. H., and Gaillard, C. A. (2014). Cardiorenal syndrome-current understanding and future perspectives. Nat. Rev. Nephrol. 10 (1), 48–55. doi:10.1038/nrneph.2013.250

PubMed Abstract | CrossRef Full Text | Google Scholar

Bragadottir, G., Redfors, B., and Ricksten, S. E. (2013). Assessing glomerular filtration rate (GFR) in critically ill patients with acute kidneyinjury-true GFR versus urinary creatinine clearance and estimating equations. Crit. Care 17 (3), R108. doi:10.1186/cc12777

PubMed Abstract | CrossRef Full Text | Google Scholar

Breidthardt, T., Socrates, T., Noveanu, M., Klima, T., Heinisch, C., Reichlin, T., et al. (2011). Effect and clinical prediction of worsening renal function in acute decompensated heart failure. Am. J. Cardiol. 107 (5), 730–735. doi:10.1016/j.amjcard.2010.10.056

PubMed Abstract | CrossRef Full Text | Google Scholar

Cao, Z., Jia, Y., and Zhu, B. (2019). BNP and NT-proBNP as diagnostic biomarkers for cardiac dysfunction in both clinical and forensic medicine. Int. J. Mol. Sci. 20 (8), 1820. doi:10.3390/ijms20081820

PubMed Abstract | CrossRef Full Text | Google Scholar

Charniot, J. C., Vignat, N., Albertini, J. P., Bogdanova, V., Zerhouni, K., Monsuez, J. J., et al. (2008). Oxidative stress in patients with acute heart failure. Rejuvenation Res. 11 (2), 393–398. doi:10.1089/rej.2008.0663

PubMed Abstract | CrossRef Full Text | Google Scholar

Chen, C., Yang, X., Lei, Y., Zha, Y., Liu, H., Ma, C., et al. (2016). Urinary biomarkers at the time of AKI diagnosis as predictors of progression of AKI among patients with acute cardiorenal syndrome. Clin. J. Am. Soc. Nephrol. 11 (9), 1536–1544. doi:10.2215/CJN.00910116

PubMed Abstract | CrossRef Full Text | Google Scholar

Cho, E., Kim, M., Ko, Y. S., Lee, H. Y., Song, M., Kim, M. G., et al. (2013). Role of inflammation in the pathogenesis of cardiorenal syndrome in a rat myocardial infarction model. Nephrol. Dial. Transpl. 28 (11), 2766–2778. doi:10.1093/ndt/gft376

PubMed Abstract | CrossRef Full Text | Google Scholar

Chu, P. Y., Mariani, J., Finch, S., McMullen, J. R., Sadoshima, J., Marshall, T., et al. (2010). Bone marrow-derived cells contribute to fibrosis in the chronically failing heart. Am. J. Pathol. 176 (4), 1735–1742. doi:10.2353/ajpath.2010.090574

PubMed Abstract | CrossRef Full Text | Google Scholar

Chu, P. Y., Zatta, A., Kiriazis, H., Chin-Dusting, J., Du, X. J., Marshall, T., et al. (2011). CXCR4 antagonism attenuates the cardiorenal consequences of mineralocorticoid excess. Circ. Heart Fail 4 (5), 651–658. doi:10.1161/CIRCHEARTFAILURE.110.960831

PubMed Abstract | CrossRef Full Text | Google Scholar

Colbert, G., Jain, N., de Lemos, J. A., and Hedayati, S. S. (2015). Utility of traditional circulating and imaging-based cardiac biomarkers in patients with predialysis CKD. Clin. J. Am. Soc. Nephrol. 10 (3), 515–529. doi:10.2215/CJN.03600414

PubMed Abstract | CrossRef Full Text | Google Scholar

Colombo, P. C., Ganda, A., Lin, J., Onat, D., Harxhi, A., Iyasere, J. E., et al. (2012). Inflammatory activation: Cardiac, renal, and cardio-renal interactions in patients with the cardiorenal syndrome. Heart Fail Rev. 17 (2), 177–190. doi:10.1007/s10741-011-9261-3

PubMed Abstract | CrossRef Full Text | Google Scholar

Costanzo, M. R. (2020). The cardiorenal syndrome in heart failure. Heart Fail Clin. 16 (1), 81–97. doi:10.1016/j.hfc.2019.08.010

PubMed Abstract | CrossRef Full Text | Google Scholar

Cowland, J. B., and Borregaard, N. (1997). Molecular characterization and pattern of tissue expression of the gene for neutrophil gelatinase-associated lipocalin from humans. Genomics 45 (1), 17–23. doi:10.1006/geno.1997.4896

PubMed Abstract | CrossRef Full Text | Google Scholar

Damman, K., Navis, G., Voors, A. A., Asselbergs, F. W., Smilde, T. D., Cleland, J. G., et al. (2007). Worsening renal function and prognosis in heart failure: Systematic review and meta-analysis. J. Card. Fail 13 (8), 599–608. doi:10.1016/j.cardfail.2007.04.008

PubMed Abstract | CrossRef Full Text | Google Scholar

Damman, K., van Deursen, V. M., Navis, G., Voors, A. A., van Veldhuisen, D. J., and Hillege, H. L. (2009). Increased central venous pressure is associated with impaired renal function and mortality in a broad spectrum of patients with cardiovascular disease. J. Am. Coll. Cardiol. 53 (7), 582–588. doi:10.1016/j.jacc.2008.08.080

PubMed Abstract | CrossRef Full Text | Google Scholar

de Vries, A. P., and Rabelink, T. J. (2013). A possible role of cystatin C in adipose tissue homeostasis may impact kidney function estimation in metabolic syndrome. Nephrol. Dial. Transpl. 28 (7), 1628–1630. doi:10.1093/ndt/gfs571

CrossRef Full Text | Google Scholar

Di Lullo, L., Bellasi, A., Barbera, V., Russo, D., Russo, L., Di Iorio, B., et al. (2017). Pathophysiology of the cardio-renal syndromes types 1-5: An uptodate. Indian Heart J. 69 (2), 255–265. doi:10.1016/j.ihj.2017.01.005

PubMed Abstract | CrossRef Full Text | Google Scholar

Du, J., Cao, X., Zou, L., Chen, Y., Guo, J., Chen, Z., et al. (2013). MicroRNA-21 and risk of severe acute kidney injury and poor outcomes after adult cardiac surgery. PLoS One 8 (5), e63390. doi:10.1371/journal.pone.0063390

PubMed Abstract | CrossRef Full Text | Google Scholar

Dunlay, S. M., Weston, S. A., Redfield, M. M., Killian, J. M., and Roger, V. L. (2008). Tumor necrosis factor-alpha and mortality in heart failure: A community study. Circulation 118 (6), 625–631. doi:10.1161/CIRCULATIONAHA.107.759191

PubMed Abstract | CrossRef Full Text | Google Scholar

Edelstein, C. L. (2008). Biomarkers of acute kidney injury. Adv. Chronic Kidney Dis. 15 (3), 222–234. doi:10.1053/j.ackd.2008.04.003

PubMed Abstract | CrossRef Full Text | Google Scholar

Eren, Z., Ozveren, O., Buvukoner, E., Kaspar, E., Degertekin, M., and Kantarci, G. (2012). A single-centre study of acute cardiorenal syndrome: Incidence, risk factors and consequences. Cardiorenal Med. 2 (3), 168–176. doi:10.1159/000337714

PubMed Abstract | CrossRef Full Text | Google Scholar

Fernando, K., Parthasarathy, R., Mathew, M., Abraham, G., Lesley, N., Muruganathan, A., et al. (2021). Risk factors and outcomes of acute cardio-renal syndrome in a tertiary care setting in south India. J. Assoc. Physicians India 69 (8), 11–12.

Google Scholar

Fu, K., Hu, Y., Zhang, H., Wang, C., Lin, Z., Lu, H., et al. (2021). Insights of worsening renal function in type 1 cardiorenal syndrome: From the pathogenesis, biomarkers to treatment. Front. Cardiovasc Med. 8, 760152. doi:10.3389/fcvm.2021.760152

PubMed Abstract | CrossRef Full Text | Google Scholar

Gai, J. J., Gai, L. Y., Liu, H. B., Wang, Z. G., Chen, L., Sun, Z. J., et al. (2010). Correlation of heart and kidney biomarkers to the pathogenesis of cardiorenal syndrome. Nan Fang. Yi Ke Da Xue Xue Bao 30 (5), 1122–1126.

PubMed Abstract | Google Scholar

Gembillo, G., Visconti, L., Giusti, M. A., Siligato, R., Gallo, A., Santoro, D., et al. (2021). Cardiorenal syndrome: New pathways and novel biomarkers. Biomolecules 11 (11), 1581. doi:10.3390/biom11111581

PubMed Abstract | CrossRef Full Text | Google Scholar

Gigante, A., Liberatori, M., Gasperini, M. L., Sardo, L., Di Mario, F., Dorelli, B., et al. (2014). Prevalence and clinical features of patients with the cardiorenal syndrome admitted to an internal medicine ward. Cardiorenal Med. 4 (2), 88–94. doi:10.1159/000362566

PubMed Abstract | CrossRef Full Text | Google Scholar

Goffredo, G., Barone, R., Di Terlizzi, V., Correale, M., Brunetti, N. D., and Iacoviello, M. (2021). Biomarkers in cardiorenal syndrome. J. Clin. Med. 10 (15), 3433. doi:10.3390/jcm10153433

PubMed Abstract | CrossRef Full Text | Google Scholar

Goldberg, A., Hammerman, H., Petcherski, S., Zdorovyak, A., Yalonetsky, S., Kapeliovich, M., et al. (2005). Inhospital and 1-year mortality of patients who develop worsening renal function following acute ST-elevation myocardial infarction. Am. Heart J. 150 (2), 330–337. doi:10.1016/j.ahj.2004.09.055

PubMed Abstract | CrossRef Full Text | Google Scholar

Gonzalez, K. A., Stickel, A. M., Kaur, S. S., Ramos, A. R., Gonzalez, H. M., and Tarraf, W. (2022). Serum Cystatin-C is linked to increased prevalence of diabetes and higher risk of mortality in diverse middle-aged and older adults. PLoS One 17 (9), e0270289. doi:10.1371/journal.pone.0270289

PubMed Abstract | CrossRef Full Text | Google Scholar

Grodin, J. L., Stevens, S. R., de Las Fuentes, L., Kiernan, M., Birati, E. Y., Gupta, D., et al. (2016). Intensification of medication therapy for cardiorenal syndrome in acute decompensated heart failure. J. Card. Fail 22 (1), 26–32. doi:10.1016/j.cardfail.2015.07.007

PubMed Abstract | CrossRef Full Text | Google Scholar

Grynberg, K., Polkinghorne, K. R., Ford, S., Stenning, F., Lew, T. E., Barrett, J. A., et al. (2017). Early serum creatinine accurately predicts acute kidney injury post cardiac surgery. BMC Nephrol. 18 (1), 93. doi:10.1186/s12882-017-0504-y

PubMed Abstract | CrossRef Full Text | Google Scholar

Haase, M., Muller, C., Damman, K., Murray, P. T., Kellum, J. A., Ronco, C., et al. (2013). Pathogenesis of cardiorenal syndrome type 1 in acute decompensated heart failure: Workgroup statements from the eleventh consensus conference of the acute dialysis quality initiative (ADQI). Contrib. Nephrol. 182, 99–116. doi:10.1159/000349969

PubMed Abstract | CrossRef Full Text | Google Scholar

Halimi, J. M., de Freminville, J. B., Gatault, P., Bisson, A., Gueguen, J., Goin, N., et al. (2022). Long-term impact of cardiorenal syndromes on major outcomes based on their chronology: A comprehensive French nationwide cohort study. Nephrol. Dial. Transpl. 37, 2386–2397. doi:10.1093/ndt/gfac153

CrossRef Full Text | Google Scholar

Hara, A., Niwa, M., Noguchi, K., Kanayama, T., Niwa, A., Matsuo, M., et al. (2020). Galectin-3 as a next-generation biomarker for detecting early stage of various diseases. Biomolecules 10 (3), 389. doi:10.3390/biom10030389

PubMed Abstract | CrossRef Full Text | Google Scholar

Hashimoto, R., Adachi, H., Nishida, H., Tsuruta, M., and Nomura, G. (1995). Serum N-acetyl-beta-D-glucosaminidase activity in predicting the development of hypertension. Hypertension 25 (6), 1311–1314. doi:10.1161/01.hyp.25.6.1311

PubMed Abstract | CrossRef Full Text | Google Scholar

Hata, N., Yokoyama, S., Shinada, T., Kobayashi, N., Shirakabe, A., Tomita, K., et al. (2010). Acute kidney injury and outcomes in acute decompensated heart failure: Evaluation of the RIFLE criteria in an acutely ill heart failure population. Eur. J. Heart Fail 12 (1), 32–37. doi:10.1093/eurjhf/hfp169

PubMed Abstract | CrossRef Full Text | Google Scholar

He, T., Zhang, Z., Staessen, J. A., Mischak, H., Latosinska, A., and Beige, J. (2021). Proteomic biomarkers in the cardiorenal syndrome: Toward deciphering molecular pathophysiology. Am. J. Hypertens. 34 (7), 669–679. doi:10.1093/ajh/hpaa201

PubMed Abstract | CrossRef Full Text | Google Scholar

Ho, J., Reslerova, M., Gali, B., Nickerson, P. W., Rush, D. N., Sood, M. M., et al. (2012). Serum creatinine measurement immediately after cardiac surgery and prediction of acute kidney injury. Am. J. Kidney Dis. 59 (2), 196–201. doi:10.1053/j.ajkd.2011.08.023

PubMed Abstract | CrossRef Full Text | Google Scholar

Holappa, M., Vapaatalo, H., and Vaajanen, A. (2020). Local ocular renin-angiotensin-aldosterone system: Any connection with intraocular pressure? A comprehensive review. Ann. Med. 52 (5), 191–206. doi:10.1080/07853890.2020.1758341

PubMed Abstract | CrossRef Full Text | Google Scholar

Hoste, E. A. J., Kellum, J. A., Selby, N. M., Zarbock, A., Palevsky, P. M., Bagshaw, S. M., et al. (2018). Global epidemiology and outcomes of acute kidney injury. Nat. Rev. Nephrol. 14 (10), 607–625. doi:10.1038/s41581-018-0052-0

PubMed Abstract | CrossRef Full Text | Google Scholar

Hosten, A. O. (1990). “BUN and creatinine,” in Clinical methods: The history, physical, and laboratory examinations. Editors H. K. Walker, W. D. Hall, and J. W. Hurst 3rd.(Boston: Butterworths).

Google Scholar

Hu, W., He, W., Liu, W., Fang, X., Wu, Y., Yu, F., et al. (2016). Risk factors and prognosis of cardiorenal syndrome type 1 in elderly Chinese patients: A retrospective observational cohort study. Kidney Blood Press Res. 41 (5), 1037–1039. doi:10.1159/000452596

PubMed Abstract | CrossRef Full Text | Google Scholar

Huang, C. K., Bar, C., and Thum, T. (2020). miR-21, mediator, and potential therapeutic target in the cardiorenal syndrome. Front. Pharmacol. 11, 726. doi:10.3389/fphar.2020.00726

PubMed Abstract | CrossRef Full Text | Google Scholar

Jensen, J., Ma, L. P., Fu, M. L., Svaninger, D., Lundberg, P. A., and Hammarsten, O. (2010). Inflammation increases NT-proBNP and the NT-proBNP/BNP ratio. Clin. Res. Cardiol. 99 (7), 445–452. doi:10.1007/s00392-010-0140-z

PubMed Abstract | CrossRef Full Text | Google Scholar

Jernberg, T., Lindahl, B., James, S., Larsson, A., Hansson, L. O., and WallentinCystatin, L. C. (2004). Cystatin C: A novel predictor of outcome in suspected or confirmed non-ST-elevation acute coronary syndrome. Circulation 110 (16), 2342–2348. doi:10.1161/01.CIR.0000145166.44942.E0

PubMed Abstract | CrossRef Full Text | Google Scholar

Jin, L., Li, Q., Li, J., Pan, Y., Zou, J., Wu, X., et al. (2021). Apela inhibits systemic and renal inflammatory reactions in mice with type I cardiorenal syndrome. FASEB J. 35 (10), e21907. doi:10.1096/fj.202101030R

PubMed Abstract | CrossRef Full Text | Google Scholar

Junho, C. V. C., Trentin-Sonoda, M., Panico, K., Dos Santos, R. S. N., Abrahao, M. V., Vernier, I. C. S., et al. (2022). Cardiorenal syndrome: Long road between kidney and heart. Heart Fail Rev. 27 (6), 2137–2153. doi:10.1007/s10741-022-10218-w

PubMed Abstract | CrossRef Full Text | Google Scholar

Kaddourah, A., Goldstein, S. L., Basu, R., Nehus, E. J., Terrell, T. C., Brunner, L., et al. (2016). Novel urinary tubular injury markers reveal an evidence of underlying kidney injury in children with reduced left ventricular systolic function: A pilot study. Pediatr. Nephrol. 31 (10), 1637–1645. doi:10.1007/s00467-016-3360-2

PubMed Abstract | CrossRef Full Text | Google Scholar

Karimi, F., Maleki, M., and Nematbakhsh, M. (2022). View of the renin-angiotensin system in acute kidney injury induced by renal ischemia-reperfusion injury. J. Renin Angiotensin Aldosterone Syst. 2022, 9800838. doi:10.1155/2022/9800838

PubMed Abstract | CrossRef Full Text | Google Scholar

Kasuno, K., Shirakawa, K., Yoshida, H., Mori, K., Kimura, H., Takahashi, N., et al. (2014). Renal redox dysregulation in AKI: Application for oxidative stress marker of AKI. Am. J. Physiol. Ren. Physiol. 307 (12), F1342–F1351. doi:10.1152/ajprenal.00381.2013

PubMed Abstract | CrossRef Full Text | Google Scholar

Kim, G. H. (2020). Hepcidin as a biomarker of cardiorenal syndrome. J. Korean Med. Sci. 35 (1), e20. doi:10.3346/jkms.2020.35.e20

PubMed Abstract | CrossRef Full Text | Google Scholar

Kirwan, C. J., Philips, B. J., and Macphee, I. A. (2013). Estimated glomerular filtration rate correlates poorly with four-hour creatinine clearance in critically ill patients with acute kidney injury. Crit. Care Res. Pract. 2013, 406075. doi:10.1155/2013/406075

PubMed Abstract | CrossRef Full Text | Google Scholar

Knight, E. L., Verhave, J. C., Spiegelman, D., Hillege, H. L., de Zeeuw, D., Curhan, G. C., et al. (2004). Factors influencing serum cystatin C levels other than renal function and the impact on renal function measurement. Kidney Int. 65 (4), 1416–1421. doi:10.1111/j.1523-1755.2004.00517.x

PubMed Abstract | CrossRef Full Text | Google Scholar

Kokkoris, S., Nanas, S., and Andrews, P. (2012). “Possible role of NGAL as an early renal biomarker,” in Annual update in intensive care and emergency medicine. Editor J. L. Vincent (Berlin: Springer), 609–617.

CrossRef Full Text | Google Scholar

Kumar, U., Wettersten, N., and Garimella, P. S. (2019). Cardiorenal syndrome: Pathophysiology. Cardiol. Clin. 37 (3), 251–265. doi:10.1016/j.ccl.2019.04.001

PubMed Abstract | CrossRef Full Text | Google Scholar

Kumaresan, R., and Giri, P. (2011). A comparison of serum cystatin C and creatinine with glomerular filtration rate in Indian patients with chronic kidney disease. Oman Med. J. 26 (6), 421–425. doi:10.5001/omj.2011.107

PubMed Abstract | CrossRef Full Text | Google Scholar

Kumarswamy, R., Volkmann, I., Jazbutyte, V., Dangwal, S., Park, D. H., and Thum, T. (2012). Transforming growth factor-beta-induced endothelial-to-mesenchymal transition is partly mediated by microRNA-21. Arterioscler. Thromb. Vasc. Biol. 32 (2), 361–369. doi:10.1161/ATVBAHA.111.234286

PubMed Abstract | CrossRef Full Text | Google Scholar

Kwon, S. H., Tang, H., Saad, A., Woollard, J. R., Lerman, A., Textor, S. C., et al. (2016). Differential expression of microRNAs in urinary extracellular vesicles obtained from hypertensive patients. Am. J. Kidney Dis. 68 (2), 331–332. doi:10.1053/j.ajkd.2016.01.027

PubMed Abstract | CrossRef Full Text | Google Scholar

Lassus, J. P., Nieminen, M. S., Peuhkurinen, K., Pulkki, K., Siirila-Waris, K., Sund, R., et al. (2010). Markers of renal function and acute kidney injury in acute heart failure: Definitions and impact on outcomes of the cardiorenal syndrome. Eur. Heart J. 31 (22), 2791–2798. doi:10.1093/eurheartj/ehq293

PubMed Abstract | CrossRef Full Text | Google Scholar

Laterza, O. F., Price, C. P., and Scott, M. G. (2002). Cystatin C: An improved estimator of glomerular filtration rate? Clin. Chem. 48 (5), 699–707. doi:10.1093/clinchem/48.5.699

PubMed Abstract | CrossRef Full Text | Google Scholar

Li, X. C., and Zhuo, J. L. (2008). Nuclear factor-kappaB as a hormonal intracellular signaling molecule: Focus on angiotensin II-induced cardiovascular and renal injury. Curr. Opin. Nephrol. Hypertens. 17 (1), 37–43. doi:10.1097/MNH.0b013e3282f2903c

PubMed Abstract | CrossRef Full Text | Google Scholar

Li, Z., Cai, L., Liang, X., Du, Z., Chen, Y., An, S., et al. (2014). Identification and predicting short-term prognosis of early cardiorenal syndrome type 1: KDIGO is superior to RIFLE or AKIN. PLoS One 9 (12), e114369. doi:10.1371/journal.pone.0114369

PubMed Abstract | CrossRef Full Text | Google Scholar

Liu, X. J., Hong, Q., Wang, Z., Yu, Y. Y., Zou, X., and Xu, L. H. (2016). MicroRNA21 promotes interstitial fibrosis via targeting DDAH1: A potential role in renal fibrosis. Mol. Cell. Biochem. 411 (1-2), 181–189. doi:10.1007/s11010-015-2580-2

PubMed Abstract | CrossRef Full Text | Google Scholar

Liu, Y., Yin, Z., Xu, X., Liu, C., Duan, X., Song, Q., et al. (2021). Crosstalk between the activated Slit2-Robo1 pathway and TGF-β1 signalling promotes cardiac fibrosis. Esc. Heart Fail 8 (1), 447–460. doi:10.1002/ehf2.13095

PubMed Abstract | CrossRef Full Text | Google Scholar

Ljungman, S., Laragh, J. H., and Cody, R. J. (1990). Role of the kidney in congestive heart failure. Relationship of cardiac index to kidney function. Drugs 39 (4), 10–21. doi:10.2165/00003495-199000394-00004

PubMed Abstract | CrossRef Full Text | Google Scholar

Logeart, D., Tabet, J. Y., Hittinger, L., Thabut, G., Jourdain, P., Maison, P., et al. (2008). Transient worsening of renal function during hospitalization for acute heart failure alters outcome. Int. J. Cardiol. 127 (2), 228–232. doi:10.1016/j.ijcard.2007.06.007

PubMed Abstract | CrossRef Full Text | Google Scholar

Long, D. A., Price, K. L., Herrera-Acosta, J., and Johnson, R. J. (2004). How does angiotensin II cause renal injury? Hypertension 43 (4), 722–723. doi:10.1161/01.HYP.0000120964.22281.3e

PubMed Abstract | CrossRef Full Text | Google Scholar

Ma, K., Gao, W., Xu, H., Liang, W., and Ma, G. (2022). Role and mechanism of the renin-angiotensin-aldosterone system in the onset and development of cardiorenal syndrome. J. Renin Angiotensin Aldosterone Syst. 2022, 3239057. doi:10.1155/2022/3239057

PubMed Abstract | CrossRef Full Text | Google Scholar

Macdonald, S., Arendts, G., Nagree, Y., and Xu, X. F. (2012). Neutrophil gelatinase-associated lipocalin (NGAL) predicts renal injury in acute decompensated cardiac failure: A prospective observational study. BMC Cardiovasc Disord. 12, 8. doi:10.1186/1471-2261-12-8

PubMed Abstract | CrossRef Full Text | Google Scholar

Marenzi, G., Cabiati, A., Bertoli, S. V., Assanelli, E., Marana, I., De Metrio, M., et al. (2013). Incidence and relevance of acute kidney injury in patients hospitalized with acute coronary syndromes. Am. J. Cardiol. 111 (6), 816–822. doi:10.1016/j.amjcard.2012.11.046

PubMed Abstract | CrossRef Full Text | Google Scholar

Martensson, J., and Bellomo, R. (2014). The rise and fall of NGAL in acute kidney injury. Blood Purif. 37 (4), 304–310. doi:10.1159/000364937

PubMed Abstract | CrossRef Full Text | Google Scholar

Medic, B., Rovcanin, B., Basta Jovanovic, G., Radojevic-Skodric, S., and Prostran, M. (2015). Kidney injury molecule-1 and cardiovascular diseases: From basic science to clinical practice. Biomed. Res. Int. 2015, 854070. doi:10.1155/2015/854070

PubMed Abstract | CrossRef Full Text | Google Scholar

Melenovsky, V., Cervenka, L., Viklicky, O., Franekova, J., Havlenova, T., Behounek, M., et al. (2018). Kidney response to heart failure: Proteomic analysis of cardiorenal syndrome. Kidney Blood Press Res. 43 (5), 1437–1450. doi:10.1159/000493657

PubMed Abstract | CrossRef Full Text | Google Scholar

Mentz, R. J., and O'Connor, C. M. (2016). Pathophysiology and clinical evaluation of acute heart failure. Nat. Rev. Cardiol. 13 (1), 28–35. doi:10.1038/nrcardio.2015.134

PubMed Abstract | CrossRef Full Text | Google Scholar

Metra, M., Nodari, S., Parrinello, G., Bordonali, T., Bugatti, S., Danesi, R., et al. (2008). Worsening renal function in patients hospitalised for acute heart failure: Clinical implications and prognostic significance. Eur. J. Heart Fail 10 (2), 188–195. doi:10.1016/j.ejheart.2008.01.011

PubMed Abstract | CrossRef Full Text | Google Scholar

Milkovic, L., Cipak Gasparovic, A., Cindric, M., Mouthuy, P. A., and Zarkovic, N. (2019). Short Overview of ROS as cell function regulators and their implications in therapy concepts. Cells 8 (8), 793. doi:10.3390/cells8080793

PubMed Abstract | CrossRef Full Text | Google Scholar

Mishra, J., Dent, C., Tarabishi, R., Mitsnefes, M. M., Ma, Q., Kelly, C., et al. (2005). Neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker for acute renal injury after cardiac surgery. Lancet 365 (9466), 1231–1238. doi:10.1016/S0140-6736(05)74811-X

PubMed Abstract | CrossRef Full Text | Google Scholar

Mishra, J., Ma, Q., Prada, A., Mitsnefes, M., Zahedi, K., Yang, J., et al. (2003). Identification of neutrophil gelatinase-associated lipocalin as a novel early urinary biomarker for ischemic renal injury. J. Am. Soc. Nephrol. 14 (10), 2534–2543. doi:10.1097/01.asn.0000088027.54400.c6

PubMed Abstract | CrossRef Full Text | Google Scholar

Molitoris, B. A. (2012). Measuring glomerular filtration rate in acute kidney injury: Yes, but not yet. Crit. Care 16 (5), 158. doi:10.1186/cc11482

PubMed Abstract | CrossRef Full Text | Google Scholar

Mullens, W., Abrahams, Z., Francis, G. S., Sokos, G., Taylor, D. O., Starling, R. C., et al. (2009). Importance of venous congestion for worsening of renal function in advanced decompensated heart failure. J. Am. Coll. Cardiol. 53 (7), 589–596. doi:10.1016/j.jacc.2008.05.068

PubMed Abstract | CrossRef Full Text | Google Scholar

Muntner, P., Winston, J., Uribarri, J., Mann, D., and Fox, C. S. (2008). Overweight, obesity, and elevated serum cystatin C levels in adults in the United States. Am. J. Med. 121 (4), 341–348. doi:10.1016/j.amjmed.2008.01.003

PubMed Abstract | CrossRef Full Text | Google Scholar

Murty, M. S., Sharma, U. K., Pandey, V. B., and Kankare, S. B. (2013). Serum cystatin C as a marker of renal function in detection of early acute kidney injury. Indian J. Nephrol. 23 (3), 180–183. doi:10.4103/0971-4065.111840

PubMed Abstract | CrossRef Full Text | Google Scholar

Nakada, Y., Kawakami, R., Matsui, M., Ueda, T., Nakano, T., Nakagawa, H., et al. (2019). Value of placental growth factor as a predictor of adverse events during the acute phase of acute decompensated heart failure. Circ. J. 83 (2), 395–400. doi:10.1253/circj.CJ-18-0523

PubMed Abstract | CrossRef Full Text | Google Scholar

Naruse, H., Ishii, J., Kawai, T., Hattori, K., Ishikawa, M., Okumura, M., et al. (2009). Cystatin C in acute heart failure without advanced renal impairment. Am. J. Med. 122 (6), 566–573. doi:10.1016/j.amjmed.2008.10.042

PubMed Abstract | CrossRef Full Text | Google Scholar

Nikorowitsch, J., Borchardt, T., Appelbaum, S., Ojeda, F., Lackner, K. J., Schnabel, R. B., et al. (2020). Cardio-renal biomarker soluble urokinase-type plasminogen activator receptor is associated with cardiovascular death and myocardial infarction in patients with coronary artery disease independent of troponin, C-reactive protein, and renal function. J. Am. Heart Assoc. 9 (8), e015452. doi:10.1161/JAHA.119.015452

PubMed Abstract | CrossRef Full Text | Google Scholar

Nunez, J., Garcia, S., Nunez, E., Bonanad, C., Bodi, V., Minana, G., et al. (2017). Early serum creatinine changes and outcomes in patients admitted for acute heart failure: The cardio-renal syndrome revisited. Eur. Heart J. Acute Cardiovasc Care 6 (5), 430–440. doi:10.1177/2048872614540094

PubMed Abstract | CrossRef Full Text | Google Scholar

Okamoto, R., Ali, Y., Hashizume, R., Suzuki, N., and Ito, M. (2019). BNP as a major player in the heart-kidney connection. Int. J. Mol. Sci. 20 (14), 3581. doi:10.3390/ijms20143581

PubMed Abstract | CrossRef Full Text | Google Scholar

Palazzuoli, A., Ruocco, G., Beltrami, M., Franci, B., Pellegrini, M., Lucani, B., et al. (2014). Admission plasma neutrophil gelatinase associated lipocalin (NGAL) predicts worsening renal function during hospitalization and post discharge outcome in patients with acute heart failure. Acute Card. Care 16 (3), 93–101. doi:10.3109/17482941.2014.911915

PubMed Abstract | CrossRef Full Text | Google Scholar

Patel, R. S., Ghasemzadeh, N., Eapen, D. J., Sher, S., Arshad, S., Ko, Y. A., et al. (2016). Novel biomarker of oxidative stress is associated with risk of death in patients with coronary artery disease. Circulation 133 (4), 361–369. doi:10.1161/CIRCULATIONAHA.115.019790

PubMed Abstract | CrossRef Full Text | Google Scholar

Peoples, J. N., Saraf, A., Ghazal, N., Pham, T. T., and Kwong, J. Q. (2019). Mitochondrial dysfunction and oxidative stress in heart disease. Exp. Mol. Med. 51 (12), 1–13. doi:10.1038/s12276-019-0355-7

PubMed Abstract | CrossRef Full Text | Google Scholar

Petra, E., He, T., Lygirou, V., Latosinska, A., Mischak, H., Vlahou, A., et al. (2021). Urine peptidome analysis in cardiorenal syndrome reflects molecular processes. Sci. Rep. 11 (1), 16219. doi:10.1038/s41598-021-95695-z

PubMed Abstract | CrossRef Full Text | Google Scholar

Phan, H. A. O. (2021). Value of combined Plasma NGAL, Cystatin C and NT-proBNP in the diagnosis of cardiorenal syndrome type 1. Eur. Heart J. 42 (1). doi:10.1093/eurheartj/ehab724.1036

CrossRef Full Text | Google Scholar

Phan Thai, H., Hoang Bui, B., Hoang Anh, T., and Huynh Van, M. (2020). Value of plasma NGAL and creatinine on first day of admission in the diagnosis of cardiorenal syndrome type 1. Cardiol. Res. Pract. 2020, 2789410. doi:10.1155/2020/2789410

PubMed Abstract | CrossRef Full Text | Google Scholar

Podzolkov, V. I. D. N. A., Kazadaeva, A. V., Belyaev, Y. G., and Tolmacheva, A. V. (2022). Galectin-3 as a marker of cardiorenal syndrome in patients with chronic heart failure. Ration. Pharmacother. Cardiol. 18 (2), 153–159. doi:10.20996/1819-6446-2022-04-04

CrossRef Full Text | Google Scholar

Prastaro, M., Nardi, E., Paolillo, S., Santoro, C., Parlati, A. L. M., Gargiulo, P., et al. (2022). Cardiorenal syndrome: Pathophysiology as a key to the therapeutic approach in an under-diagnosed disease. J. Clin. Ultrasound 50 (8), 1110–1124. doi:10.1002/jcu.23265

PubMed Abstract | CrossRef Full Text | Google Scholar

Price, J. F., Mott, A. R., Dickerson, H. A., Jefferies, J. L., Nelson, D. P., Chang, A. C., et al. (2008). Worsening renal function in children hospitalized with decompensated heart failure: Evidence for a pediatric cardiorenal syndrome? Pediatr. Crit. Care Med. 9 (3), 279–284. doi:10.1097/PCC.0b013e31816c6ed1

PubMed Abstract | CrossRef Full Text | Google Scholar

Prothasis, M., Varma, A., Gaidhane, S., Kumar, S., Khatib, N., Zahiruddin, Q. S., et al. (2020). Prevalence, types, risk factors, and outcomes of cardiorenal syndrome in a rural population of central India: A cross-sectional study. J. Fam. Med. Prim. Care 9 (8), 4127–4133. doi:10.4103/jfmpc.jfmpc_533_20

PubMed Abstract | CrossRef Full Text | Google Scholar

Qian, H., Tang, C., and Yan, G. (2019). Predictive value of blood urea nitrogen/creatinine ratio in the long-term prognosis of patients with acute myocardial infarction complicated with acute heart failure. Med. Baltim. 98 (11), e14845. doi:10.1097/MD.0000000000014845

PubMed Abstract | CrossRef Full Text | Google Scholar

Rachwan, R. J., Butler, J., Collins, S. P., Cotter, G., Davison, B. A., Senger, S., et al. (2019). Is plasma renin activity associated with worse outcomes in acute heart failure? A secondary analysis from the BLAST-AHF trial. Eur. J. Heart Fail 21 (12), 1561–1570. doi:10.1002/ejhf.1607

PubMed Abstract | CrossRef Full Text | Google Scholar

Rajapakse, N. W., De Miguel, C., Das, S., and Mattson, D. L. (2008). Exogenous L-arginine ameliorates angiotensin II-induced hypertension and renal damage in rats. Hypertension 52 (6), 1084–1090. doi:10.1161/HYPERTENSIONAHA.108.114298

PubMed Abstract | CrossRef Full Text | Google Scholar

Rangaswami, J., Bhalla, V., Blair, J. E. A., Chang, T. I., Costa, S., Lentine, K. L., et al. (2019). Cardiorenal syndrome: Classification, pathophysiology, diagnosis, and treatment strategies: A scientific statement from the American heart association. Circulation 139 (16), e840–e878. doi:10.1161/CIR.0000000000000664

PubMed Abstract | CrossRef Full Text | Google Scholar

Reddy, M., Madappa, N., Hegde, A., and Prakash, V. (2020). A prospective single center study to assess the incidence and risk factors associated with cardiorenal syndrome with respect to its subtypes. J. Pract. Cardiovasc. Sci. 6 (2), 162–168. doi:10.4103/jpcs.jpcs_57_20

CrossRef Full Text | Google Scholar

Riehle, C., and Bauersachs, J. (2019). Key inflammatory mechanisms underlying heart failure. Herz 44 (2), 96–106. doi:10.1007/s00059-019-4785-8

PubMed Abstract | CrossRef Full Text | Google Scholar

Ronco, C., Cicoira, M., and McCullough, P. A. (2012). Cardiorenal syndrome type 1: Pathophysiological crosstalk leading to combined heart and kidney dysfunction in the setting of acutely decompensated heart failure. J. Am. Coll. Cardiol. 60 (12), 1031–1042. doi:10.1016/j.jacc.2012.01.077

PubMed Abstract | CrossRef Full Text | Google Scholar

Ronco, C., Cruz, D., and Noland, B. W. (2012). Neutrophil gelatinase-associated lipocalin curve and neutrophil gelatinase-associated lipocalin extended-range assay: A new biomarker approach in the early diagnosis of acute kidney injury and cardio-renal syndrome. Semin. Nephrol. 32 (1), 121–128. doi:10.1016/j.semnephrol.2011.11.015

PubMed Abstract | CrossRef Full Text | Google Scholar

Ronco, C., Haapio, M., House, A. A., Anavekar, N., and Bellomo, R. (2008). Cardiorenal syndrome. J. Am. Coll. Cardiol. 52 (19), 1527–1539. doi:10.1016/j.jacc.2008.07.051

PubMed Abstract | CrossRef Full Text | Google Scholar

Ronco, C., McCullough, P., Anker, S. D., Anand, I., Aspromonte, N., Bagshaw, S. M., et al. (2010). Cardio-renal syndromes: Report from the consensus conference of the acute dialysis quality initiative. Eur. Heart J. 31 (6), 703–711. doi:10.1093/eurheartj/ehp507

PubMed Abstract | CrossRef Full Text | Google Scholar

Roy, A. K., Mc Gorrian, C., Treacy, C., Kavanaugh, E., Brennan, A., Mahon, N. G., et al. (2013). A comparison of traditional and novel definitions (RIFLE, AKIN, and KDIGO) of acute kidney injury for the prediction of outcomes in acute decompensated heart failure. Cardiorenal Med. 3 (1), 26–37. doi:10.1159/000347037

PubMed Abstract | CrossRef Full Text | Google Scholar

Sabatine, M. S., Morrow, D. A., de Lemos, J. A., Omland, T., Desai, M. Y., Tanasijevic, M., et al. (2004). Acute changes in circulating natriuretic peptide levels in relation to myocardial ischemia. J. Am. Coll. Cardiol. 44 (10), 1988–1995. doi:10.1016/j.jacc.2004.07.057

PubMed Abstract | CrossRef Full Text | Google Scholar

Sabbisetti, V. S., Waikar, S. S., Antoine, D. J., Smiles, A., Wang, C., Ravisankar, A., et al. (2014). Blood kidney injury molecule-1 is a biomarker of acute and chronic kidney injury and predicts progression to ESRD in type I diabetes. J. Am. Soc. Nephrol. 25 (10), 2177–2186. doi:10.1681/ASN.2013070758

PubMed Abstract | CrossRef Full Text | Google Scholar

Sakyi, S. A., Ephraim, R. K. D., Adoba, P., Amoani, B., Buckman, T., Mantey, R., et al. (2021). Tissue inhibitor metalloproteinase 2 (TIMP-2) and insulin-like growth factor binding protein 7 (IGFBP7) best predicts the development of acute kidney injury. Heliyon 7 (9), e07960. doi:10.1016/j.heliyon.2021.e07960

PubMed Abstract | CrossRef Full Text | Google Scholar

Sarohi, V., Chakraborty, S., and Basak, T. (2022). Exploring the cardiac ECM during fibrosis: A new era with next-gen proteomics. Front. Mol. Biosci. 9, 1030226. doi:10.3389/fmolb.2022.1030226

PubMed Abstract | CrossRef Full Text | Google Scholar

Sarohi, V., Srivastava, S., and Basak, T. (2022). A comprehensive outlook on dilated cardiomyopathy (DCM): State-Of-The-Art developments with special emphasis on OMICS-based approaches. J. Cardiovasc Dev. Dis. 9 (6), 174. doi:10.3390/jcdd9060174

PubMed Abstract | CrossRef Full Text | Google Scholar

Seckinger, D., Ritter, O., and Patschan, D. (2022). Risk factors and outcome variables of cardiorenal syndrome type 1 from the nephrologist's perspective. Int. Urol. Nephrol. 54 (7), 1591–1601. doi:10.1007/s11255-021-03036-w

PubMed Abstract | CrossRef Full Text | Google Scholar

Seki, M., Nakayama, M., Sakoh, T., Yoshitomi, R., Fukui, A., Katafuchi, E., et al. (2019). Blood urea nitrogen is independently associated with renal outcomes in Japanese patients with stage 3-5 chronic kidney disease: A prospective observational study. BMC Nephrol. 20 (1), 115. doi:10.1186/s12882-019-1306-1

PubMed Abstract | CrossRef Full Text | Google Scholar

Shah, H. R., Singh, N. P., Aggarwal, N. P., Singhania, D., and Kumar, A. (2016). Cardiorenal syndrome: Clinical outcome study. J. Assoc. Physicians India 64 (12), 41–46.

PubMed Abstract | Google Scholar

Sharma, N., Anders, H. J., and Gaikwad, A. B. (2019). Fiend and friend in the renin angiotensin system: An insight on acute kidney injury. Biomed. Pharmacother. 110, 764–774. doi:10.1016/j.biopha.2018.12.018

PubMed Abstract | CrossRef Full Text | Google Scholar

Shi, S., Zhang, B., Li, Y., Xu, X., Lv, J., Jia, Q., et al. (2022). Mitochondrial dysfunction: An emerging link in the pathophysiology of cardiorenal syndrome. Front. Cardiovasc Med. 9, 837270. doi:10.3389/fcvm.2022.837270

PubMed Abstract | CrossRef Full Text | Google Scholar

Shirakabe, A., Hata, N., Kobayashi, N., Shinada, T., Tomita, K., Tsurumi, M., et al. (2013). Prognostic impact of acute kidney injury in patients with acute decompensated heart failure. Circ. J. 77 (3), 687–696. doi:10.1253/circj.cj-12-0994

PubMed Abstract | CrossRef Full Text | Google Scholar

Shlipak, M. G., Mattes, M. D., and Peralta, C. A. (2013). Update on cystatin C: Incorporation into clinical practice. Am. J. Kidney Dis. 62 (3), 595–603. doi:10.1053/j.ajkd.2013.03.027

PubMed Abstract | CrossRef Full Text | Google Scholar

Song, J., Yu, J., Prayogo, G. W., Cao, W., Wu, Y., Jia, Z., et al. (2019). Understanding kidney injury molecule 1: A novel immune factor in kidney pathophysiology. Am. J. Transl. Res. 11 (3), 1219–1229.

PubMed Abstract | Google Scholar

Song, X., Cai, D., and Zhang, B. (2021). Clinical values of serum NGAL combined with NT-proBNP in the early prognosis of type 1 cardiorenal syndrome. Am. J. Transl. Res. 13 (4), 3363–3368.

PubMed Abstract | Google Scholar

Sun, I. O., and Lerman, L. O. (2019). Urinary microRNA in kidney disease: Utility and roles. Am. J. Physiol. Ren. Physiol. 316 (5), F785–F93. doi:10.1152/ajprenal.00368.2018

PubMed Abstract | CrossRef Full Text | Google Scholar

Sun, Y. B., Liu, B. C., Zou, Y., Pan, J. R., Tao, Y., and Yang, M. (2016). Risk factors of acute kidney injury after acute myocardial infarction. Ren. Fail 38 (9), 1353–1358. doi:10.3109/0886022X.2016.1148558

PubMed Abstract | CrossRef Full Text | Google Scholar

Takahama, H., and Kitakaze, M. (2017). Pathophysiology of cardiorenal syndrome in patients with heart failure: Potential therapeutic targets. Am. J. Physiol. Heart Circ. Physiol. 313 (4), H715–H21. doi:10.1152/ajpheart.00215.2017

PubMed Abstract | CrossRef Full Text | Google Scholar

Takimoto, E., and Kass, D. A. (2007). Role of oxidative stress in cardiac hypertrophy and remodeling. Hypertension 49 (2), 241–248. doi:10.1161/01.HYP.0000254415.31362.a7

PubMed Abstract | CrossRef Full Text | Google Scholar

Tan, K., and Sethi, S. K. (2014). Biomarkers in cardiorenal syndromes. Transl. Res. 164 (2), 122–134. doi:10.1016/j.trsl.2014.04.011

PubMed Abstract | CrossRef Full Text | Google Scholar

Tanaka, S., Tanaka, T., and Nangaku, M. (2014). Hypoxia as a key player in the AKI-to-CKD transition. Am. J. Physiol. Ren. Physiol. 307 (11), F1187–F1195. doi:10.1152/ajprenal.00425.2014

PubMed Abstract | CrossRef Full Text | Google Scholar

Tandon, R., Mohan, B., Chhabra, S. T., Aslam, N., and Wander, G. S. (2013). Clinical and echocardiographic predictors of cardiorenal syndrome type I in patients with acute ischemic right ventricular dysfunction. Cardiorenal Med. 3 (4), 239–245. doi:10.1159/000355524

PubMed Abstract | CrossRef Full Text | Google Scholar

Uduman, J. (2018). Epidemiology of cardiorenal syndrome. Adv. Chronic Kidney Dis. 25 (5), 391–399. doi:10.1053/j.ackd.2018.08.009

PubMed Abstract | CrossRef Full Text | Google Scholar

van der Pol, A., van Gilst, W. H., Voors, A. A., and van der Meer, P. (2019). Treating oxidative stress in heart failure: Past, present and future. Eur. J. Heart Fail 21 (4), 425–435. doi:10.1002/ejhf.1320

PubMed Abstract | CrossRef Full Text | Google Scholar

Van Linthout, S., Miteva, K., and Tschope, C. (2014). Crosstalk between fibroblasts and inflammatory cells. Cardiovasc Res. 102 (2), 258–269. doi:10.1093/cvr/cvu062

PubMed Abstract | CrossRef Full Text | Google Scholar

Vandenberghe, W., Gevaert, S., Kellum, J. A., Bagshaw, S. M., Peperstraete, H., Herck, I., et al. (2016). Acute kidney injury in cardiorenal syndrome type 1 patients: A systematic review and meta-analysis. Cardiorenal Med. 6 (2), 116–128. doi:10.1159/000442300

PubMed Abstract | CrossRef Full Text | Google Scholar

Verbrugge, F. H., Tang, W. H., and Mullens, W. (2015). Renin-Angiotensin-aldosterone system activation during decongestion in acute heart failure: Friend or foe? JACC Heart Fail 3 (2), 108–111. doi:10.1016/j.jchf.2014.10.005

PubMed Abstract | CrossRef Full Text | Google Scholar

Virzi, G. M., Breglia, A., Brocca, A., de Cal, M., Bolin, C., Vescovo, G., et al. (2018). Levels of proinflammatory cytokines, oxidative stress, and tissue damage markers in patients with acute heart failure with and without cardiorenal syndrome type 1. Cardiorenal Med. 8 (4), 321–331. doi:10.1159/000492602

PubMed Abstract | CrossRef Full Text | Google Scholar

Virzi, G. M., Clementi, A., Brocca, A., de Cal, M., Vescovo, G., Granata, A., et al. (2014). The hemodynamic and nonhemodynamic crosstalk in cardiorenal syndrome type 1. Cardiorenal Med. 4 (2), 103–112. doi:10.1159/000362650

PubMed Abstract | CrossRef Full Text | Google Scholar

Virzi, G. M., Torregrossa, R., Cruz, D. N., Chionh, C. Y., de Cal, M., Soni, S. S., et al. (2012). Cardiorenal syndrome type 1 may Be immunologically mediated: A pilot evaluation of monocyte apoptosis. Cardiorenal Med. 2 (1), 33–42. doi:10.1159/000335499

PubMed Abstract | CrossRef Full Text | Google Scholar

Viswanathan, G., and Gilbert, S. (2010). The cardiorenal syndrome: Making the connection. Int. J. Nephrol. 2011, 283137. doi:10.4061/2011/283137

PubMed Abstract | CrossRef Full Text | Google Scholar

Wang, K., Ni, G., Wu, Q., Zhou, Y., Yao, W., Zhang, H., et al. (2020). Prognostic value of N-terminal pro-B-type natriuretic peptide and glomerular filtration rate in patients with acute heart failure. Front. Cardiovasc Med. 7, 123. doi:10.3389/fcvm.2020.00123

PubMed Abstract | CrossRef Full Text | Google Scholar

Weber, K. T., and Brilla, C. G. (1991). Pathological hypertrophy and cardiac interstitium. Fibrosis and renin-angiotensin-aldosterone system. Circulation 83 (6), 1849–1865. doi:10.1161/01.cir.83.6.1849

PubMed Abstract | CrossRef Full Text | Google Scholar

Welsh, P., Campbell, R. T., Mooney, L., Kimenai, D. M., Hayward, C., Campbell, A., et al. (2022). Reference ranges for NT-proBNP (N-terminal pro-B-type natriuretic peptide) and risk factors for higher NT-proBNP concentrations in a large general population cohort. Circ. Heart Fail 15 (10), e009427. doi:10.1161/CIRCHEARTFAILURE.121.009427

PubMed Abstract | CrossRef Full Text | Google Scholar

Werner, R. A., Hess, A., Koenig, T., Diekmann, J., Derlin, T., Melk, A., et al. (2021). Molecular imaging of inflammation crosstalk along the cardio-renal axis following acute myocardial infarction. Theranostics 11 (16), 7984–7994. doi:10.7150/thno.61423

PubMed Abstract | CrossRef Full Text | Google Scholar

Yu, A. S. L. Brenner and rector's the kidney, 12, ed2020.

Yuan, A., Lee, Y., Choi, U., Moeckel, G., and Karihaloo, A. (2015). Chemokine receptor Cxcr4 contributes to kidney fibrosis via multiple effectors. Am. J. Physiol. Ren. Physiol. 308 (5), F459–F472. doi:10.1152/ajprenal.00146.2014

PubMed Abstract | CrossRef Full Text | Google Scholar

Zappitelli, M., Bernier, P. L., Saczkowski, R. S., Tchervenkov, C. I., Gottesman, R., Dancea, A., et al. (2009). A small post-operative rise in serum creatinine predicts acute kidney injury in children undergoing cardiac surgery. Kidney Int. 76 (8), 885–892. doi:10.1038/ki.2009.270

PubMed Abstract | CrossRef Full Text | Google Scholar

Zhang, Z., Humphreys, B. D., and Bonventre, J. V. (2007). Shedding of the urinary biomarker kidney injury molecule-1 (KIM-1) is regulated by MAP kinases and juxtamembrane region. J. Am. Soc. Nephrol. 18 (10), 2704–2714. doi:10.1681/ASN.2007030325

PubMed Abstract | CrossRef Full Text | Google Scholar

Zhou, S.-S., Jin, J.-P., Wang, J.-Q., Zhang, Z.-G., Freedman, J. H., Zheng, Y., et al. (2018). miRNAS in cardiovascular diseases: potential biomarkers, therapeutic targets and challenges. Acta Pharmacol. Sin. 39 (7), 1073–1084. doi:10.1038/aps.2018.30

PubMed Abstract | CrossRef Full Text | Google Scholar

Zhu, Q., Dong, H., Bukhari, A. A., Zhao, A., Li, M., Sun, Y., et al. (2020). HUWE1 promotes EGFR ubiquitination and degradation to protect against renal tubulointerstitial fibrosis. FASEB J. 34 (3), 4591–4601. doi:10.1096/fj.201902751R

PubMed Abstract | CrossRef Full Text | Google Scholar

Keywords: cardiorenal syndrome, heart failure, fibrosis, proteomics, biomarkers, kidney failure

Citation: Dutta A, Saha S, Bahl A, Mittal A and Basak T (2023) A comprehensive review of acute cardio-renal syndrome: need for novel biomarkers. Front. Pharmacol. 14:1152055. doi: 10.3389/fphar.2023.1152055

Received: 27 January 2023; Accepted: 03 May 2023;
Published: 23 May 2023.

Edited by:

Yogesh A. Kulkarni, SVKM’s Narsee Monjee Institute of Management Studies, India

Reviewed by:

Anil Bhanudas Gaikwad, Birla Institute of Technology and Science, India
Avijit Hazra, Institute of Postgraduate Medical Education and Research, India

Copyright © 2023 Dutta, Saha, Bahl, Mittal and Basak. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

*Correspondence: Trayambak Basak, dHJheWFtYmFrQGlpdG1hbmRpLmFjLmlu; Anupam Mittal, bWl0dGFsLmFudXBhbUBwZ2ltZXIuZWR1Lmlu

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