SYSTEMATIC REVIEW article
Front. Pharmacol.
Sec. Experimental Pharmacology and Drug Discovery
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1501330
Analysis of research trends and development prospects of soluble guanylate cyclase stimulators/activators: using bibliometric methods
Provisionally accepted
- First Affiliated Hospital of Jinzhou Medical University, Jinzhou, China
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The stimulation and activation of soluble guanylate cyclase (sGC) has been a prominent focus of study in recent years. Currently, sGC stimulators/activators have a wide range of applications in various fields. However, there remains a gap in bibliometric analysis on this topic. We aim to visualize the research hotspots and trends in the field of sGC stimulators or activators. This analysis can equip researchers to understand current findings and forecast future trends efficiently.The researchers searched for publications on sGC stimulators or activators in Web of Science Core Collection (WoSCC) on July 22, 2024. We then organized and analyzed the data using Microsoft Excel, online tool (Weishengxin), R, VOS viewer, and CiteSpace.Results: 1879 papers from WoSCC were gathered for analysis, comprising 1582 articles and 297 reviews. The USA is the most productive country. And Germany stands out as the country with the most robust collaboration. The most productive institution is BAYER AG. Furthermore, the majority of journals with citation frequencies in the top 10 belong to Q1. The Professor Stasch, JP is the most prolific author and the top co-cited author. Currently, the influential keywords include "riociguat", "outcome", "guanylate cyclase stimulator", "heart failure", "natriuretic peptide", "vericiguat", "reduced ejection fraction", "mortality" and "placebo".The future research hotspots will focus on the following aspects based on the current research hotspots: the safety verification of riociguat, the clinical efficacy of vericiguat for other types of heart failure, the role of praliciguat in diabetes nephropathy, and the efficacy and safety of newly discovered drugs. Furthermore, actively exploring new therapeutic directions for sGC stimulators or activators may also be an important trend in the future development of this field.
Keywords: Bibliometric, Soluble guanylate cyclase (sGC) stimulator, Soluble Guanylate Cyclase (sGC) Activator, Riociguat, vericiguat
Received: 27 Sep 2024; Accepted: 16 May 2025.
Copyright: © 2025 Zhang, Yan, Wang and Yuan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Jun Wang, First Affiliated Hospital of Jinzhou Medical University, Jinzhou, China
Hongxia Yuan, First Affiliated Hospital of Jinzhou Medical University, Jinzhou, China
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