ORIGINAL RESEARCH article
Front. Pharmacol.
Sec. Experimental Pharmacology and Drug Discovery
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1542729
This article is part of the Research TopicInsights in Experimental Pharmacology and Drug Discovery: 2024View all 10 articles
Innovative application of mefloquine and methacycline in combating Tet(X3/X4)-positive Escherichia coli infections
Provisionally accepted
- 1Ningxia University, Yinchuan, China
- 2Jilin University, Changchun, Hebei Province, China
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The advent and global spread of plasmid-carried resistance genes, including the tigecycline resistance gene tet(X3/X4) and the colistin resistance gene mcr-1, present a substantial threat to public health that requires immediate resolution. This study successfully screened and identified commercial anti-parasitic drugs that efficiently inhibit Tet(X4) enzyme activity (IC50 = 79.42 μg/mL), revealing that mefloquine exhibited a synergistic antibacterial effect with tetracyclines against tet(X3/X4)-positive bacteria (FIC<0.5) and an additive effect with tetracyclines against tet(X3/X4)-negative bacteria (0.5
Keywords: Mefloquine, Methacycline, tet(X4), synergistic effect, Escherichia coli
Received: 10 Dec 2024; Accepted: 28 Feb 2025.
Copyright: © 2025 Zhou, Zhou and Xue. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yonglin Zhou, Ningxia University, Yinchuan, China
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