REVIEW article
Front. Pharmacol.
Sec. Respiratory Pharmacology
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1551452
This article is part of the Research TopicTranslational Strategies for Chronic Lung Diseases: Emerging Therapies and Precision MedicineView all 4 articles
Unlocking the secrets of glucose metabolism reprogramming: The role in pulmonary diseases
Provisionally accepted
- 1Hunan University of Medicine, Huaihua, China
- 2Qiandongnan People's Hospital, Affiliated Hospital of Guizhou Medical University, Kaili, China
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Metabolic reprogramming is the process by which cells adapt to different patterns of energy metabolism in response to the demands of the microenvironment for energy and biological macromolecules. Glucose serves as the primary energy source for cellular survival, and its metabolic pathways are intricately associated with cellular functional states. Recent studies have demonstrated that alterations in glucose metabolism, along with non-metabolic functions of metabolic enzymes and metabolites, play crucial roles in the development and progression of lung diseases under inflammatory conditions. This review summarizes the regulatory mechanisms of glucose metabolism across various pulmonary disorders and discusses the non-metabolic functions of glycolytic enzymes and metabolites in relation to disease pathogenesis. We aim to shine new light on the diagnosis and treatment of lung disease.
Keywords: Glucose metabolism reprogramming, Pneumonia, Acute Respiratory Distress Syndrome, chronic obstructive pulmonary disease, lung cancer, Pulmonary Fibrosis
Received: 09 May 2025; Accepted: 28 Jul 2025.
Copyright: © 2025 Li, Chen, Jiang, Yang and Yan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yinong Yang, Hunan University of Medicine, Huaihua, China
Xichan Yan, Qiandongnan People's Hospital, Affiliated Hospital of Guizhou Medical University, Kaili, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.