CASE REPORT article
Front. Pharmacol.
Sec. Respiratory Pharmacology
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1555377
Case Report: Coadministration of TNF-α Blockade as an Effective Adjunctive Strategy in the Treatment of ANCA-Negative EGPA with Refractory Peripheral Neuropathy
Provisionally accepted
- 1The Fourth Clinical Medical College, Guangzhou University of Chinese Medicine, Shenzhen, China
- 2The Department of Rheumatology, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen, China
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Eosinophilic granulomatosis with polyangiitis (EGPA) is characterized by abnormal eosinophilia and extravascular eosinophilic granuloma formation.Conventional treatments combining glucocorticoids and immunosuppressants can alleviate the condition in most patients with EGPA.However, the efficacy of blocking tumor necrosis factor (TNF)-α-mediated inflammatory reactions in managing EGPA remains controversial. Here, we report a case of refractory EGPA that did not respond to glucocorticoid pulse therapy and adequate cyclophosphamide. The disease was ultimately controlled through the coadministration of etanercept.
Keywords: Eosinophilic granulomatosis with polyangiitis, Eosinophilia, refractory peripheral neuropathy, TNF-α blockade, etanercept
Received: 04 Jan 2025; Accepted: 27 Jun 2025.
Copyright: © 2025 Tang, Jiang, Yang, Wei, Xie and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Jingjing Xie, The Department of Rheumatology, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen, China
Jianyong Zhang, The Department of Rheumatology, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen, China
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