REVIEW article
Front. Pharmacol.
Sec. Ethnopharmacology
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1566479
This article is part of the Research TopicTraditional, Complementary and Integrative Medicine – Opportunities for Managing and Treating Neurodegenerative Diseases and Ischaemic StrokeView all 16 articles
Research progress on the mechanisms of polysaccharides derived from traditional Chinese medicine in the treatment of Parkinson's disease
Provisionally accepted
Xiangling Zhou
Qi Pan*- People’s Hospital of Dong xihu, Wuhan, China
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Parkinson's disease (PD) is currently a highly prevalent neurodegenerative disease.Its pathogenesis is complex, and there is no effective method to prevent the disease progression. Traditional Chinese medicine (TCM) has a unique advantage in treating PD through the approach of syndrome differentiation. TCM prescriptions for PD can reduce Unified Parkinson's Disease Rating Scale (UPDRS) scores, improve nonmotor symptoms, and decrease adverse drug reactions. Bioactive polysaccharides extracted from prescribed Chinese herbs exhibit diverse biological activities due to their wide range of botanical sources. This review summarizes the pharmacological mechanisms of TCM polysaccharides in managing PD, including inhibition of apoptosis, activation of autophagy, regulation of inflammation, anti-oxidative stress, improvement of mitochondrial function, and neuroprotective effects, aiming to provide a theoretical basis for future research and treatment.
Keywords: Polysaccharides, Traditional Chinese Medicine, Parkinson's Disease;, pharmacological mechanisms, Neuroprotection, Research progress
Received: 24 Jan 2025; Accepted: 14 Jul 2025.
Copyright: © 2025 Zhou and Pan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Qi Pan, People’s Hospital of Dong xihu, Wuhan, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.