ORIGINAL RESEARCH article
Front. Pharmacol.
Sec. Ethnopharmacology
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1567205
Mechanistic Insights into Clary Sage Oils Role in Wound Healing: Targeting Oxidative Stress and Inflammatory Pathways
Provisionally accepted
Rehab Ahmed1
Krishnaraju Venkatesan2
Durgaramani Sivadasan3
Nizar Sirag1
Hassabelrasoul Abdelgadir1
Gayathri Anbumani4*Debadrita Saha5- 1Faculty of Pharmacy, University of Tabuk, Tabuk, Saudi Arabia
- 2King Khalid University, Abha, Saudi Arabia
- 3Jazan University, Jizan, Saudi Arabia
- 4Kaarunee VRK Lifesciences, Chennai, India, Chennai, Tamil Nadu, India
- 5College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur, Tamil Nadu, India
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Clary sage essential oil (CSEO), extracted from Salvia sclarea, is esteemed for its medicinal qualities, including antioxidant and anti-inflammatory effects. This study investigates the mechanism by which CSEO promotes wound healing, with particular emphasis on its ability to modulate oxidative stress and the expression of inflammatory cytokines in an animal model.The excision wound model was employed in rats to evaluate the wound-healing potential of CSEO. The treatment group received topical application of CSEO, and its effects were assessed through biochemical, molecular, and histological analyses. Results demonstrated a significant acceleration in wound contraction and epithelialization in CSEO-treated groups compared to controls. Biochemical studies revealed a marked reduction in oxidative stress markers, indicating an enhancement of the cellular antioxidant defense system and a potential restoration of redox balance. The reduced oxidative stress has downregulated CD68, thereby reducing TNF-α and IL-6 levels, highlighting its anti-inflammatory effects. Histopathological examination confirmed improved granulation tissue formation, collagen deposition, and angiogenesis in treated wounds, accompanied by reduced inflammatory infiltration. These findings highlight the dual function of CSEO in reducing inflammation and augmenting antioxidant activity, essential for efficient wound healing. In conclusion, CSEO demonstrates a promising, multi-targeted approach to wound healing by effectively modulating oxidative stress, inflammatory responses, and CD68 expression. Its potential as a natural therapeutic warrants further exploration for clinical applications in regenerative medicine.
Keywords: Clary Sage Oil, Salvia sclarea, Wound Healing, inflammatory cytokines, Homeostasis
Received: 26 Jan 2025; Accepted: 29 May 2025.
Copyright: © 2025 Ahmed, Venkatesan, Sivadasan, Sirag, Abdelgadir, Anbumani and Saha. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Gayathri Anbumani, Kaarunee VRK Lifesciences, Chennai, India, Chennai, Tamil Nadu, India
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.