CASE REPORT article
Front. Pharmacol.
Sec. Predictive Toxicology
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1567380
A Case of Sudden Death Due to Occupational Nicotine Poisoning: Clinical Presentation and MRI Findings
Provisionally accepted
- 1Department of Poisoning and Occupational Diseases, Qilu Hospital, Shandong University, Jinan, Shandong Province, China
- 2School of Public Health, Shandong University, Jinan, Shandong Province, China
- 3Department of Nursing, Qilu Hospital, Shandong University, Jinan, Shandong Province, China
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Background: Nicotine is a toxic alkaloid commonly found in tobacco products. This paper presents the clinical case of a patient who was exposed to a nicotine-laden waste liquid. Case Presentation: A 24-year-old male arrived at a local hospital in a state of coma and cardiac arrest. Following successful cardiopulmonary resuscitation, he was transferred to our facility for further treatment. Magnetic resonance imaging of the patient's head and neck revealed bilateral ischemic infarctions in the hippocampal region. After 24 days of treatment, the patient was discharged with significant improvement. Discussion: This case highlights the potential for severe clinical manifestations to arise shortly after a single exposure to a substantial amount of nicotine. Conclusion: In clinical practice, it is crucial to promptly assess the patient's occupational history to identify the cause of the condition, closely monitor vital signs, and provide active supportive and symptomatic care. Additionally, this case underscores the importance of ensuring production safety and increasing awareness regarding occupational exposure risks.
Keywords: Nicotine poisoning1, Occupational exposure 2, Event 3, Sudden death 4, Post cardiopulmonary resuscitation 5
Received: 27 Jan 2025; Accepted: 11 Aug 2025.
Copyright: © 2025 Liu, Liu, Jian and Kan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Xiang Dong Jian, Department of Poisoning and Occupational Diseases, Qilu Hospital, Shandong University, Jinan, 250012, Shandong Province, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.