MINI REVIEW article
Front. Pharmacol.
Sec. Translational Pharmacology
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1569020
Metabolite 2-Aminoadipic Acid: Implications for Metabolic Disorders and Therapeutic Opportunities
Provisionally accepted
- 1School of Medicine, Xiamen University, Xiamen, Fujian, China
- 2Department of Cardiology, Xiang'an Hospital, Xiamen University, Xiamen, Fujian Province, China
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Previous evidence has indicated that the role of 2-aminoadipic acid (2-AAA), a derivative of lysine catabolism, in mediating specific detrimental effects on glial cells, notably inhibiting astrocyte activation. In addition, intrathecal administration of 2-AAA has demonstrated significant efficacy in relieving mechanical hyperalgesia. With the growing application of metabolomics in biomedical research, substantial evidence now underscores 2-AAA's pivotal role in regulating glucose and lipid metabolism. As a novel biomarker, 2-AAA is linked to increased susceptibility to diabetes and has emerged as a critical regulator of glucose homeostasis. This review explores recent advancements in understanding 2-AAA's potential therapeutic applications, particularly in the context of metabolic diseases such as diabetes, obesity, and atherosclerosis. It also addresses existing research gaps and outlines future directions for developing 2-AAA-based therapies.
Keywords: Mini Review lysine metabolism, 2-Aminoadipic Acid, diabetes, Obesity, Atherosclerosis
Received: 31 Jan 2025; Accepted: 30 Apr 2025.
Copyright: © 2025 Shi, Yang, Fu and Yang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yang Yang, School of Medicine, Xiamen University, Xiamen, 361102, Fujian, China
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