REVIEW article
Front. Pharmacol.
Sec. Gastrointestinal and Hepatic Pharmacology
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1569927
Role of the Annexin A Protein Family in Liver Diseases: Insights and Therapeutic Opportunities
Provisionally accepted
- 1Department of Infectious Diseases, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, Shanghai Municipality, China
- 2Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CAS), Shanghai, Shanghai Municipality, China
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The Annexin (ANXA) protein family, which is ubiquitously expressed across various tissues, encodes versatile calcium (Ca²⁺)-and phospholipid-binding proteins that play crucial roles in modulating inflammation and cell signaling pathways. This family significantly influences several essential cellular processes, including cell adhesion, proliferation, migration, differentiation, and apoptosis. ANXAs are integral to physiological regulation and the pathological states associated with liver diseases. Dysregulated expression of ANXAs has been linked to a spectrum of liver conditions, including metabolic dysfunction, hepatocyte damage, fibrosis, and tumor formation. In this review, we outline recent advancements in understanding the roles of ANXAs in liver diseases. Further investigation into the roles of ANXAs in the liver could enhance our understanding of the mechanisms underlying liver diseases and may identify biomarkers and therapeutic targets for liver diseases in the future.
Keywords: Annexins, AnxA2, Liver disease, MAFLD, HCC
Received: 02 Feb 2025; Accepted: 26 Jun 2025.
Copyright: © 2025 Feng, He and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Hui Wang, Department of Infectious Diseases, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200025, Shanghai Municipality, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.