REVIEW article
Front. Pharmacol.
Sec. Ethnopharmacology
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1573901
This article is part of the Research TopicHerbal Medicines’ Safety and Clinical Application: New Strategies for Overcoming Therapeutic ChallengesView all 14 articles
Modulating TRPV1 and TRPA1 channels: A viable strategy for treating asthma using Chinese herbal medicines
Provisionally accepted
- 1State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, China
- 2Sichuan Sanlian New Material Co., Ltd., Chengdu, China
- 3Innovative Institute of Chinese Medicine and Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, China
- 4Sichuan Engineering Research Center for Endangered Medicinal Animals, Chengdu, China
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Asthma represents a significant global health challenge, imposing a substantial burden on society worldwide. Over the past decades, the development of asthma medications has significantly reduced asthma-related mortality. However, current pharmacological treatment regimens have not yet demonstrated the capacity to induce a durable remission of asthma. Transient receptor potential (TRP) channels, specifically vanilloid receptor 1 (TRPV1) and ankyrin 1 (TRPA1), are polymodal sensory channels extensively distributed in the lungs and represent promising therapeutic targets for asthma. Increasing evidence suggests that Chinese herbal medicines (CHM) exert beneficial effects in asthma treatment by modulating TRPV1/TRPA1. Therefore, this study systematically analyzed 134 articles covering the pathogenesis of asthma, current treatment strategies, the role of TRPV1/TRPA1 in asthma, and the modulation of TRPV1/TRPA1 by CHM in asthma. In summary, our review comprehensively elaborates on how CHM modulates TRPV1/TRPA1 channels to alleviate pulmonary inflammation. These findings provide viable options for asthma drug discovery and establish the foundation for developing effective CHM-based therapeutics.
Keywords: Asthma, Alleviation, TRPV1/TRPA1 channels, modulation, Chinese herbal medicines
Received: 10 Feb 2025; Accepted: 18 Jun 2025.
Copyright: © 2025 Yao, Zhang, Cui, Jian, Wu, Wu and Tao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Xuejian Zhang, Sichuan Sanlian New Material Co., Ltd., Chengdu, China
Chunjie Wu, Innovative Institute of Chinese Medicine and Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, Sichuan Province, China
Feiyan Tao, Sichuan Sanlian New Material Co., Ltd., Chengdu, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.