REVIEW article
Front. Pharmacol.
Sec. Ethnopharmacology
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1575903
This article is part of the Research TopicReviews in Ethnopharmacology: 2025View all 20 articles
Clinical application, POTENTIAL pharmacological TARGETS and quality marker prediction of A TCM FORMULATION USED (Shenling Baizhu San) in the treatment of respiratory diseases
Provisionally accepted
- Shandong University of Traditional Chinese Medicine, Jinan, China
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Shenling Baizhu San (SLBZS) is a formulation of traditional Chinese medicine (TCM) recorded in the Song Dynasty medical book Taiping Huimin Heji Jufang (AD 1078-1085). It comprises eleven herbs: Ginseng Radix Et Rhizoma, Atractylodis Macrocephalae Rhizoma, Poria, Dioscoreae Rhizoma, Nelumbinis Semen, Coicis Semen, Lablab Semen Album, Amomi Fructus, Platycodonis Radix, Glycyrrhizae Radix Et Rhizoma, and Jujubae Fructus. SLBZS has been employed for over 900 years in the treatment of pulmonary and gastrointestinal disorders because of its qualities that enhance spleen function, tonify the lungs, supplement qi, and mitigate diarrhoea. This study meticulously examined and synthesised the clinical relevance and pharmacological mechanisms of SLBZS, concentrating on respiratory diseases, in response to the increasing volume of clinical data about SLBZS. Meanwhile, according to the five principles of Q-marker determination, including quality transmission and traceability, metabolites specificity, formula compatibility environment, association between metabolites and effectiveness, metabolites measurability, the potential quality markers (Q-markers) that SLBZS in the treatment of respiratory diseases were predicted. This study will provide additional clinical research, clarify pharmacological mechanisms, and set quality control criteria for SLBZS in the treatment of respiratory diseases.
Keywords: Shenling Baizhu San, Respiratory diseases, clinical application, pharmacological mechanisms, Quality markers
Received: 13 Feb 2025; Accepted: 16 May 2025.
Copyright: © 2025 Gao, Wang, Fu, Wu, Wang, Wu, Lu, Ou, Zhao and Yu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Haijun Zhao, Shandong University of Traditional Chinese Medicine, Jinan, China
Huayun Yu, Shandong University of Traditional Chinese Medicine, Jinan, China
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