SYSTEMATIC REVIEW article
Front. Pharmacol.
Sec. Ethnopharmacology
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1578783
Therapeutic Potential of Chinese Herbal Medicine for Coronary Heart Disease Patients with Cerebral Ischemic Stroke: A Systematic Review and Meta-Analysis
Provisionally accepted
- 1Liaoning University of Traditional Chinese Medicine, Shenyang, China
- 2Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning Province, China
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Objective: This research sought to demonstrate potential therapeutic strategies for coronary heart disease (CHD) patients with cerebral ischemic stroke (CIS) by rigorously evaluating the efficacy and safety of Chinese Herbal Medicine (CHM) through meta-analysis. Methods: A broad search approach was applied to obtain pertinent articles from both domestic and international databases, covering publications up to December 31, 2024. Using RevMan software (Version 5.4), a systematic review and meta-analysis were conducted to assess the efficacy and safety of CHM in treating CHD patients with CIS. Results: In the meta-analysis, 18 trails were analyzed, encompassing 2,202 patients in total. The aggregated findings indicated that the utilization of CHM improved the overall effective rate, ECG performance and TCM scores significantly. Furthermore, the CHM therapy demonstrated significant improvements in LVEF, MMSE, and NIHSS. Additionally, the CHMs therapy positively influenced lipid profiles, specifically TC, TG, LDL-C, and HDL-C. Notably, the application of CHM during the intervention was particularly effective in reducing blood viscosity, fibrinogen and platelet aggregation. Importantly, the CHM therapy was found to provide comparable safety profile to that of conventional western medicine treatment (WM) alone. Conclusion: The CHM demonstrated superior efficacy in the management of CHD patients with CIS. Concurrently, the CHM showed potential for improving neurological damage, lipid profiles, and positively affecting hemorheological parameters, all while minimizing the risk of adverse effects. Even so, because of the limitations in study quality and the potential for reporting bias, it is crucial that these findings require to be further validated through rigorous, large-scale, and high-quality RCT in future research.
Keywords: Cerebral ischemic stroke, Chinese herbal medicine, systematic review and meta-analysis, coronary heart disease, Cardiovascular and cerebrovascular chronic diseases
Received: 18 Feb 2025; Accepted: 23 Jun 2025.
Copyright: © 2025 Du, Ao, Wang, Chen, Guanghui and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Rui Du, Liaoning University of Traditional Chinese Medicine, Shenyang, China
Mingxue Zhang, Liaoning University of Traditional Chinese Medicine, Shenyang, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.