CASE REPORT article
Front. Pharmacol.
Sec. Predictive Toxicology
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1580170
Infliximab for Hydroxychloroquine-Induced AGEP with IL17A and IL36RN Mutations: A Case Report and Management Considerations
Provisionally accepted
- Department of Dermatology, Sir Run Run Shaw Hospital, Hangzhou, China
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Acute generalized exanthematous pustulosis (AGEP) is a severe cutaneous drug reaction that typically resolves rapidly following withdrawal of the offending drug and administration of systemic corticosteroids. Infliximab, a biologic agent that inhibits TNF-α, is widely used in the treatment of various inflammatory diseases. Individuals with specific genetic risk factors may be more susceptible to severe drug-induced cutaneous reactions. Here, we report the first case of successful infliximab treatment in a pregnant woman with IL17A and IL36RN mutations who developed severe AGEP after 24 days of hydroxychloroquine use and failed to respond to conventional therapy.
Keywords: infliximab, Hydroxychloroquine, AGEP, IL17A, IL36RN, pregnant
Received: 20 Feb 2025; Accepted: 07 Jul 2025.
Copyright: © 2025 Jiang, Hua, Feng and Cheng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Hao Cheng, Department of Dermatology, Sir Run Run Shaw Hospital, Hangzhou, China
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