BRIEF RESEARCH REPORT article
Front. Pharmacol.
Sec. Pharmacoepidemiology
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1585126
Adefovir Dipivoxil-associated Fanconi syndrome combined with peripheral neuropathy: a case report and literature review
Provisionally accepted
- 1Second Clinical Medical College, Guangzhou University of Traditional Chinese Medicine, Guangzhou, China
- 2Department of Neurology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China
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Long-term use of low-dose adefovir dipivoxil (ADV) has been increasingly associated with Fanconi syndrome; however, cases of Fanconi syndrome combined with peripheral neuropathy remain rare. Here, we report a 67-year-old man who developed progressive limb weakness and sensory abnormalities after approximately 6 years of treatment with 10 mg ADV. He was diagnosed with ADVassociated Fanconi syndrome accompanied by peripheral neuropathy. Following the substitution of ADV with entecavir and 5 months of phosphate supplementation, the patient's muscle weakness nearly resolved, and peripheral nerve damage showed significant improvement.
Keywords: Fanconi Syndrome, Adefovir dipivoxil, peripheral neuropathy, Hypophosphatemia, Energy metabolism F -Latency(ms) 33.2/29.3
Received: 28 Feb 2025; Accepted: 14 Jul 2025.
Copyright: © 2025 Fu, Wu, Zhao and Zhao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yuanqi Zhao, Department of Neurology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China
Min Zhao, Department of Neurology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China
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