REVIEW article
Front. Pharmacol.
Sec. Ethnopharmacology
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1586345
This article is part of the Research TopicTraditional, Complementary and Integrative Medicine – Opportunities for Managing and Treating Neurodegenerative Diseases and Ischaemic StrokeView all 9 articles
Targeting Ferroptosis with Natural Products in Stroke: Therapeutic Mechanisms and Translational Opportunities
Provisionally accepted
- Second Clinical Medical College, Guangzhou University of Traditional Chinese Medicine, Guangzhou, Guangdong Province, China
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Ferroptosis is a new type of controlled cell death. It is distinguished by its reliance on iron and the production of lipid peroxidation. The role of ferroptosis in stroke has attracted a lot of attention recently. The purpose of this review is to clarify the connection between ferroptosis and stroke and to investigate the potential contribution of natural products to the clinical management of stroke and the discovery of novel medications. In this review, we summarize in detail the mechanism of ferroptosis after stroke, especially the relevant targets of ferroptosis after stroke. Furthermore, we summarize the natural products and herbal medicine currently employed in ferroptosis along with their mechanisms of action, highlighting the potential and challenges of clinical translation. The purpose of this review is to accelerate the development of novel natural and herbal medicine treatments and to offer novel perspectives on how to treat ferroptosis in stroke.
Keywords: Natural Products, Stroke, ferroptosis, Phytomedicine, intracerebral hemorrhage, ischemic stroke
Received: 02 Mar 2025; Accepted: 15 May 2025.
Copyright: © 2025 Zheng, Tan, Wang, Mao and Guo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Jianwen Guo, Second Clinical Medical College, Guangzhou University of Traditional Chinese Medicine, Guangzhou, 510000, Guangdong Province, China
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