Knowledge graph and emerging trends in oxidative stress research on hepatic ischemia-reperfusion injury: A bibliometric analysis (1995-2024)

Simeng LeiYangkai FuBo ZhangHanwen YangZhili Ji^*

• Beijing Chaoyang Hospital, Capital Medical University, Beijing, China

Hepatic ischemia-reperfusion injury (HIRI) is common in many surgical procedures involving the liver, particularly liver transplantation and extensive hepatectomy, where there is a period of ischemia or hypoxia followed by a return to normal blood flow. Oxidative stress refers to increased intracellular levels of reactive oxygen species (ROS), usually caused by an imbalance between the production and scavenging of oxidized free radicals. Oxidative stress plays a key role in the pathophysiology of HIRI and has attracted considerable research interest. This bibliometric analysis aims to provide a comprehensive review of global trends and research priorities in the study of oxidative stress in HIRI between 1995 and 2024. It provides valuable information and guidelines for future researchers. After screening, we finalized 2,367 articles, and the number of articles by country/map and collaborative network map showed that the number of articles in this field is increasing, with China and the United States dominating the field, Wuhan University, Sun Yat-sen University, and Shanghai Jiaotong University are in the top three in terms of published articles. From the perspective of keyword emergence, over the past 30 years, researchers around the world have progressed from the discovery and understanding of the role of oxidative stress in HIRI, to basic experiments and preliminary therapeutic explorations using experimental animals, and now to studies related to donor protection and postoperative therapies. In conclusion, this is a bibliometric analysis on the study of oxidative stress in HIRI. We hope that our relevant summary and analysis will provide an idea for future researchers in related fields and further promote further research in this field.