REVIEW article
Front. Pharmacol.
Sec. Pharmacology of Anti-Cancer Drugs
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1587675
Role and Therapeutic Potential of the NEDD4 Family in Breast Cancer
Provisionally accepted
Xiaoxiao Zhang1
Sijie Li1,2*- 1Department of Breast surgery, General Surgery Center, the First Hospital of Jilin University, Changchun, China
- 2Jilin University, Changchun, China
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The high incidence and mortality rates of breast cancer (BC) continue to pose a significant threat to patient survival and life expectancy. An increasing number of recent studies have demonstrated the crucial role of the ubiquitin-proteasome system (UPS) in cancer initiation and progression.Of particular significance is the aberrant expression of the NEDD4 family, which belongs to the HECT-type E3 ubiquitin ligases, in BC progression. This review synthesizes current knowledge about the interactions between the NEDD4 family and various tumor-related signaling pathways and their roles in BC biology, providing a theoretical foundation for exploring novel prognostic markers and treatment strategies.
Keywords: breast cancer, Ubiquitin, Nedd4, Protac, TGF-β
Received: 04 Mar 2025; Accepted: 22 May 2025.
Copyright: © 2025 Zhang and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Sijie Li, Jilin University, Changchun, China
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