SYSTEMATIC REVIEW article
Front. Pharmacol.
Sec. Ethnopharmacology
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1588284
This article is part of the Research TopicBioactivities and Clinical Applications of Medicinal Plants in Promoting Wellness in AgingView all 4 articles
Effects of resveratrol on postmenopausal women: a systematic review and meta-analysis
Provisionally accepted
- 1Heilongjiang University of Chinese Medicine, Harbin, China
- 2China Academy of Chinese Medical Sciences, Beijing, Beijing Municipality, China
- 3Yubei District Hospital of Traditional Chinese Medicine, Chongqing, China
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Objectives: This meta-analysis aims to systematically evaluate the impact of resveratrol on postmenopausal women. Methods: We searched seven electronic databases and conducted meta-analyses using Stata 12.0. Results: Ten randomized clinical trials (RCTs) with 928 participants were identified. Resveratrol significantly reduced pain scores (WMD: -2.841, 95% CI: -5.631 to -0.050, p=0.046), pain VAS scores (WMD: -7.585, 95% CI: -12.912 to -2.257, p=0.005), PPI scores (WMD: -8.563, 95% CI: -12.866 to -4.261, p<0.001), and CTX levels (WMD: -0.137, 95% CI: -0.204 to -0.070, p<0.001). However, no significant effects were observed on cognition and memory (e.g., PVT, ORR, PSM, RAVLT, LSWM, FSS, DCCS, FICA, TMT), mood (depression, overall mood), metabolic parameters (glucose, insulin, HOMA-IR, triglycerides, total cholesterol, LDL-C, HDL-C), blood pressure, sleep disturbance, menopausal symptoms, SF-36 quality of life, or bone markers ALP and OC. Conclusion: Resveratrol may improve pain and bone metabolism (CTX) in postmenopausal women but did not affect other examined outcomes. Future large-scale trials are needed to confirm these findings and determine optimal dosing and treatment strategies.
Keywords: resveratrol, postmenopausal women, bone metabolism, Systematic review, Meta-analysis
Received: 05 Mar 2025; Accepted: 14 Jul 2025.
Copyright: © 2025 Wu, Meng, Jin, Li, Huang, Guo, Yu and Zhou. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yanyan Zhou, Heilongjiang University of Chinese Medicine, Harbin, China
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