REVIEW article
Front. Pharmacol.
Sec. Translational Pharmacology
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1591675
This article is part of the Research TopicImmunological Aspects of Fibrosis Pathogenesis: Novel Mechanisms and Therapeutic StrategiesView all 30 articles
Research Progress on DNA Hydroxymethylation in Atrial Fibrillation: a review
Provisionally accepted
- 1China Aerospace Science & Industry Corporation 731 Hospital, Beijing, China
- 2Department of Cardiology, Guang'anmen Hospital of China Academy of Chinese Medical Sciences, Beijing, Beijing, China
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Epigenetic modifications play a critical role in the pathogenesis and progression of cardiovascular diseases. Among these, DNA hydroxymethylation has garnered increasing attention in the fields of oncology, hematology, and neurological disorders, serving as a key mechanism for untangling molecular pathways underlying disease etiology. Although emerging evidence has begun to illuminate the role of DNA hydroxymethylation in cardiovascular conditions such as coronary artery disease and atherosclerosis, its implications in atrial fibrillation remain underexplored. This review aims to summarize current understanding and discuss potential mechanisms through which DNA hydroxymethylation may contribute to the development and progression of atrial fibrillation.
Keywords: DNA hydroxymethylation, Atrial Fibrillation, 5-Hydroxymethylcytosine, Oxidative Stress, Calcium Signaling
Received: 11 Mar 2025; Accepted: 18 Sep 2025.
Copyright: © 2025 Fan and Shi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Shaowei Fan, 478525970@qq.com
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