ORIGINAL RESEARCH article
Front. Pharmacol.
Sec. Drugs Outcomes Research and Policies
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1592158
This article is part of the Research TopicIncreasing Importance of Patients-generated Real World Data for Healthcare Policy Decisions about Medicinal Products: Volume IIIView all 9 articles
Multidisciplinary Administrative-Professional-Technical Interventions to Optimize Antibiotic Use and Reduce Resistance in a Tertiary General Hospital
Provisionally accepted
- 1Renmin Hospital of Wuhan University, Wuhan, China
- 2School of Medicine, Wuhan University, Wuhan, Hebei Province, China
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Introduction:Antimicrobial stewardship (AMS) is a cornerstone of global antimicrobial resistance (AMR) strategies. However, substantial differences exist in AMS implementation approaches and effectiveness among medical institutions across nations and regions.This study aimed to evaluate strategies focused on antibiotic utilization and AMR in a tertiary general hospital. Methods: This study was conducted in two phases: the baseline phase (January to June in 2023) and the intervention phase (July 2023 to June 2024). During the intervention phase, an innovative AMS strategy integrating multidisciplinary administrative, professional, and technical interventions were implemented to reduce antibiotic use and control antimicrobial resistance. Results: After intervention, the antibiotic utilization rate among inpatients decreased from 56.01% to 52.71% (P<0.001). The Antibiotic Use Density (AUD) decreased from 50.15 to 35.76 Defined Daily Doses (DDDs) per 100 patient-days (P<0.001). The antibiotic utilization rates and AUD dropped significantly in medical, surgical, obstetrics and gynecology wards. Moreover, the intervention effect in pediatric ward displayed complex seasonal variation.The AUD for most antibiotic classes was significantly lower after the intervention. The detection rates of carbapenem-resistant Klebsiella pneumoniae and Acinetobacter baumannii decreased from 26.00% to 17.53% and 89.58% to 62.93%, respectively. Conclusion: The findings indicate that a multifaceted AMS strategy, integrating multidisciplinary administrative, professional, and technical interventions, offer an potentially effective strategy for reducing antibiotic utilization and combating AMR in the tertiary general hospital.
Keywords: Antimicrobial stewardship, antimicrobial resistance, Medical institution, Multidisciplinary collaboration, Antimicrobial management
Received: 12 Mar 2025; Accepted: 19 Aug 2025.
Copyright: © 2025 Han, Shen and Rao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yan Rao, School of Medicine, Wuhan University, Wuhan, 430071, Hebei Province, China
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