REVIEW article
Front. Pharmacol.
Sec. Ethnopharmacology
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1594278
Sweroside: Unveiling Broad Therapeutic Potential-From Mechanistic Insights to Clinical Potential
Provisionally accepted
- 1Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China
- 2School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, China
- 3Institute of Material Medica Integration and Transformation for Brain Disorders, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, China
- 4Department of General Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China
- 5Meishan Hospital, Chengdu University of Traditional Chinese Medicine, Meishan, China
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Background: Sweroside, a secoiridoid glycoside abundantly present in medicinal plants, has garnered significant attention due to its diverse bioactivities, including antiinflammatory, antioxidant, hepatoprotective, antidiabetic, antibacterial, and anticancer effects. Additionally, it exhibits promising potential in neuroprotection and dermatological health.Purpose: This review aims to provide a comprehensive analysis of Sweroside, focusing on its sources, biosynthetic pathways, pharmacodynamic mechanisms, and therapeutic potential. The insights presented aim to facilitate the development of novel pharmacotherapies and advance precision medicine.Methods: A systematic review of the literature was conducted using databases such as PubMed, Web of Science, and Google Scholar. The study examined Sweroside's sources, distribution, biosynthesis, pharmacodynamics, and therapeutic applications. Challenges in its clinical translation were also evaluated, with proposed strategies to enhance bioavailability.Results: Sweroside modulates critical signaling pathways, such as NF-κB, mTOR, MAPK, and PI3K/Akt, and their molecular substrates, contributing to its therapeutic effects across various pathological conditions. Preclinical studies demonstrate its efficacy in treating hepatic disorders, osteoporosis, cardiovascular diseases, and neurological dysfunctions. It also shows promise in neuroprotection and dermatological health. However, clinical translation is hindered by its low bioavailability and rapid metabolic degradation.Conclusion: Sweroside is a versatile natural metabolite with multi-target therapeutic potential, positioning it as a promising candidate for next-generation pharmacotherapies. To realize its clinical potential, future research should prioritize optimizing its pharmacokinetics, including enhancing bioavailability and developing
Keywords: Sweroside, Iridoid Glycosides, anti-inflammatory, antioxidant, metabolic disorders, natural product
Received: 17 Mar 2025; Accepted: 14 Jul 2025.
Copyright: © 2025 Liu, Zuo, Qiu, Lan, Wen and Ye. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Xiao-qin Ye, Meishan Hospital, Chengdu University of Traditional Chinese Medicine, Meishan, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.