REVIEW article
Front. Pharmacol.
Sec. Neuropharmacology
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1599167
Molecular mechanisms of neuroprotective effect of rutin
Provisionally accepted
Chunmei Zhang1*
Shuai Wang2- 1Luoyang Polytechnic, Luoyang, China
- 2Shenzhen Traditional Chinese Medicine Hospital, Shenzhen ，Guangdong, China
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Neurological diseases, including stroke, Alzheimer's disease, Parkinson's disease, and diabetic neuropathy, pose a significant global health burden. The rising incidence of these diseases, driven by factors including an aging population, lifestyle changes, and environmental influences, has intensified the urgent need for effective neuroprotective therapies. Rutin, a natural flavonoid glycoside widely distributed in various plants including buckwheat, citrus fruits, and onions, has garnered significant attention as a promising neuroprotective agent. This review comprehensively evaluates the current research on rutin's multifaceted neuroprotective mechanisms, which encompass antioxidant, anti-inflammatory, anti-apoptotic, antidepressant, anticonvulsant, and analgesic effects, as well as its role in enhancing neural signal transduction, improving learning and memory, and protecting the blood-brain barrier.However, despite its broad spectrum of neuroprotective effects and favorable safety profile, the clinical application of rutin is currently limited by its relatively low bioavailability. To address this limitation and fully harness rutin's therapeutic potential, future research should prioritize the development of innovative formulations designed to enhance its bioavailability.
Keywords: Rutin, antioxidant, anti-inflammatory, neuroprotective effects, mechanisms, Medicinal potential
Received: 26 Mar 2025; Accepted: 19 May 2025.
Copyright: © 2025 Zhang and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Chunmei Zhang, Luoyang Polytechnic, Luoyang, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.