REVIEW article
Front. Pharmacol.
Sec. Experimental Pharmacology and Drug Discovery
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1601537
This article is part of the Research TopicPharmacological Mechanisms of Drugs Affecting Bone Formation and Bone Resorption Volume IIView all 20 articles
Eucommia ulmoides Oliv. and Its Bioactive Compounds: Therapeutic Potential in Bone Diseases
Provisionally accepted
- 1Department of Integrated Traditional Chinese and Western Medicine, Wuhan Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China
- 2Wuhan Sports University, Wuhan, Hubei Province, China
- 3Department of Pain, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyChina, Wuhan, Hebei Province, China
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Background: Aging-related bone diseases encompass a range of conditions that emerge or worsen with advancing age, including osteoporosis and osteoarthritis, and they are placing an increasing burden on society. Although these diseases differ in clinical manifestations and pathological features, they often share common ageassociated mechanisms such as impaired bone remodeling, chronic low-grade inflammation, cellular senescence, oxidative stress, and hormonal changes. Current therapies often face limitations in efficacy or long-term safety, highlighting the need for alternative strategies. Phytochemicals derived from Chinese medicine herb have emerged as promising candidates due to their multi-target effects on bone homeostasis. Eucommia ulmoides Oliv. (EU) and its bioactive compounds (e.g., quercetin, aucubin, geniposide, geniposidic acid) may regulate key pathways to restore bone balance, offering potential for treating osteoporosis and other agingrelated bone diseases.Objectives: This study aims to assess the therapeutic potential of EU in the treatment of aging-related bone diseases.Methods: A literature search was conducted on the PubMed database up to November 2024 using the search term: "Eucommia AND (bone OR cartilage OR joint)."Results: The review indicates that EU formulas, extracts, and bioactive components promote osteogenesis, suppress bone resorption, and exert anti-inflammatory and antioxidant properties. These effects contribute positively to the treatment of agingrelated bone diseases.Conclusions: The therapeutic benefits of EU support its development as a promising tool for preventing and treating aging-related bone diseases. These findings provide new research directions to address related health challenges associated with population aging.
Keywords: Eucommia ulmoides Oliv., bioactive compounds, aging-related bone diseases, Bone formation, Bone Resorption, pharmacological mechanisms
Received: 28 Mar 2025; Accepted: 09 Jun 2025.
Copyright: © 2025 Huang, Jin, Zhang, Wang, He and Shuai. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Bo Shuai, Department of Integrated Traditional Chinese and Western Medicine, Wuhan Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, Hubei Province, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.