ORIGINAL RESEARCH article
Front. Pharmacol.
Sec. Experimental Pharmacology and Drug Discovery
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1602971
This article is part of the Research TopicReactive Oxygen Species (ROS) in Nanomedicine: Innovations, Challenges, and Future DirectionsView all articles
Multimodal Endovascular Management of Traumatic Carotid-Cavernous Fistulas: Case Series and Lessons Learned
Provisionally accepted
- Jiangmen Wuyi Tranditional Chinese Medicine Hospital, Jiangmen, China
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Traumatic carotid-cavernous fistulas (CCFs) are rare but potentially life-threatening vascular anomalies resulting from head trauma. Oxidative stress markedly disrupts resolution and vascular function, significantly hindering recovery. This study presents a case series of six patients diagnosed with CCFs following traumatic events. The cases highlight the complexity of clinical presentation, imaging findings, and treatment approaches, emphasizing the role of advanced endovascular techniques in managing these conditions. Patients underwent a combination of coil embolization, stent-assisted embolization, and balloon-assisted occlusion, demonstrating the necessity of personalized multimodal treatment strategies. Postoperative outcomes varied, with most patients achieving fistula closure and symptom stabilization, although visual impairments persisted in some cases. This study highlights the importance of prompt diagnosis, interdisciplinary collaboration, and personalized evolving endovascular interventions in optimizing patient outcomes in traumatic CCFs
Keywords: Traumatic carotid-cavernous fistula, endovascular treatment, Coil embolization, stent-assisted embolization, Multimodal management
Received: 30 Mar 2025; Accepted: 20 May 2025.
Copyright: © 2025 Yang, Chen, Yi and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Chuangnan Li, Jiangmen Wuyi Tranditional Chinese Medicine Hospital, Jiangmen, China
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