REVIEW article
Front. Pharmacol.
Sec. Ethnopharmacology
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1603417
This article is part of the Research TopicTraditional, Complementary and Integrative Medicine – Opportunities for Managing and Treating Neurodegenerative Diseases and Ischaemic StrokeView all 15 articles
Modulation of Neuroinflammation by Natural Plant Compounds: A Promising Approach for Ischemic Stroke
Provisionally accepted
- 1Huzhou Central Hospital, Huzhou, China
- 2Zhejiang Chinese Medical University, Hangzhou, Zhejiang Province, China
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Ischemic stroke remains a leading global cause of mortality and long-term disability, imposing substantial health and economic burdens on society. Although interventions such as intravenous thrombolysis and mechanical thrombectomy have proven effective, their narrow therapeutic time window restricts accessibility for many patients. Post-ischemic brain injury is significantly driven by a cascade involving inflammatory cells and mediators, culminating in an "inflammatory storm" that damages neuronal cells. Consequently, targeting neuroinflammation following ischemic stroke to explore potential therapeutic strategies is of paramount importance. Natural plant compounds, bioactive constituents derived from plants, demonstrate considerable promise for ischemic stroke treatment, with many exhibiting potent neuroinflammation-modulating activities. This review synthesizes current research on natural plant compounds targeting post-ischemic stroke neuroinflammation and elucidates their underlying mechanisms of action. It aims to offer insights for developing plant-derived therapeutics specifically targeting neuroinflammation after ischemic stroke.
Keywords: ischemic stroke, natural plant compounds, Neuroinflammation, neuroprotecti ve, anti-inflammation
Received: 31 Mar 2025; Accepted: 08 Jul 2025.
Copyright: © 2025 Niu, Zhang, Wang, Qiu, Dong, Li and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Liqin Li, Huzhou Central Hospital, Huzhou, China
Yuntao Li, Zhejiang Chinese Medical University, Hangzhou, 310053, Zhejiang Province, China
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