REVIEW article
Front. Pharmacol.
Sec. Ethnopharmacology
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1604765
Regulation of Transient Receptor Potential Ankyrin 1 by Traditional Chinese Medicine Drugs and Their Active Ingredients
Provisionally accepted
Yunlong Fang1,2
Chunxin Lei1,2
Zihan Wang1,2
Longxiao Liu1,2
Yanyu Chen1,2Feng Chen1,3Jingxuan Li1,4Zhikun Tu1,3
Qingwen Tao1*
YUAN XU1*- 1China-Japan Friendship Hospital, Beijing, China
- 2Beijing University of Chinese Medicine, Beijing, Beijing Municipality, China
- 3Yunnan University of Traditional Chinese Medicine, Kunming, Yunnan Province, China
- 4Shanxi University of Chinese Medicine, Taiyuan, Shanxi Province, China
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Transient receptor potential ankyrin 1 (TRPA1) has attracted substantial attention for its role as a thermal receptor and regulator of temperature and pain sensing. Notably, Traditional Chinese Medicine (TCM) has demonstrated pharmacological effects through regulation of TRPA1. In this review, we summarize the regulatory effects of TCM drugs and their active ingredients on TRPA1. A total of 31 TCM drugs were identified and categorized into three groups based on their function. Despite the progress in understanding the regulatory effects of TCM drugs and their constituents on TRPA1, further studies are needed to elucidate the molecular mechanisms involved. This review provides a molecular basis for the pharmacological effects of TCM drugs on TRPA1 regulation and offers evidence to support future research in this area.
Keywords: TRPA1, Traditional Chinese Medicine, Chinese herbal medicinal properties, natural compounds, Pain, Hyperalgesia, inflammatory disease
Received: 02 Apr 2025; Accepted: 27 May 2025.
Copyright: © 2025 Fang, Lei, Wang, Liu, Chen, Chen, Li, Tu, Tao and XU. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Qingwen Tao, China-Japan Friendship Hospital, Beijing, China
YUAN XU, China-Japan Friendship Hospital, Beijing, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.