CORRECTION article
Front. Pharmacol.
Sec. Experimental Pharmacology and Drug Discovery
Volume 16 - 2025 | doi: 10.3389/fphar.2025.1611105
Neuroprotective effects of a novel peptide through the Rho-integrin-Tie2 and PI3K/Akt pathways in experimental autoimmune encephalomyelitis model
Provisionally accepted
- 1Department of Emergency Medicine, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China
- 2Institute of Anatomy and Cell Biology, Medical College, Zhejiang University, Hangzhou, Jiangsu Province, China
- 3Institute of Human Anatomy, Histology and Embryology, Basic Medical College, Zhejiang Chinese Medical University, Hangzhou, China
- 4Department of Rehabilitation in Traditional Chinese Medicine, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China
- 5Department of Pulmonology, Children’s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China
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Corrigendum on: Zhou W, Qu H, Fu X-X, Xu M-M, Li Q, Jiang Y and Han S (2024), Neuroprotective effects of a novel peptide through the Rho-integrin-Tie2 and PI3K/Akt pathways in experimental autoimmune encephalomyelitis model. Front. Pharmacol. 15:1290128. doi: 10.3389/fphar.2024.1290128 In the published article, there was an error in Supplementary Figure S7 as published. The magnification of subfigure S of Supplementary Figure S7 is different from others. The corrected Supplementary Figure S7 and its caption Effects of C16, C16+Tie-2 inhibitor, and C16+PI3K inhibitor on neuron apoptosis induced by EAE. (A-J) TUNEL staining showed apoptotic neurons (double stained by hematoxylin-eosin staining). (K-T) Immunohistochemistry staining of cleaved caspase-3 detected apoptotic neurons in each group. (U-V) Quantification analysis of TUNEL and cleaved caspase-3-labeled cells in different groups. (Left, box plot; Right, dot plot). n = 5 per group. *, p < 0.05 vs. normal control group; #, p < 0.05 vs. vehicle group; &, p < 0.05 vs. C16 group; @, p < 0.05 vs. C16+Tie-2 inhibitor group. Tissues from the spinal cord and motor cortex were used for imaging analysis. Scale bar = 100 μm. Kruskal-Wallis nonparametric one-way ANOVA followed by post hoc analysis was used to analyze data presented as percentages. appear below.
Keywords: C16, EAE, Tie2, integrin, PI3K/Akt pathways
Received: 13 Apr 2025; Accepted: 29 May 2025.
Copyright: © 2025 Zhou, Qu, Fu, Xu, Li, Jiang and Han. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Qiang Li, Department of Emergency Medicine, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China
Yuan Jiang, Department of Pulmonology, Children’s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China
Shu Han, Institute of Anatomy and Cell Biology, Medical College, Zhejiang University, Hangzhou, Jiangsu Province, China
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